Name: Xuyun Zhao

Title： Investigator

Email: xuyunzhao@shsmu.edu.cn

Tel: +86-21-63846590-776538

Research Interests

We investigate noncoding RNAs, RNA binding proteins and membrane transport proteins in the control of 1) brown fat thermogenesis and energy expenditure in obesity and diabetes 2) hepatocyte function in NASH pathogenesis.

Ten Selected Papers

*co-corresponding authors; #co-first authors

1.Zhao XY*, Zhou L, Chen Z, Ji Y, Peng X, Qi L, Li S, Lin JD*. The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance. Sci Adv. 2020 May 13;6(20):eaay6191

2.Liu T, Mi L, Xiong J, Orchard P, Yu Q, Yu L, Zhao XY, Meng Z, Parker S, Lin JD, Li S. BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning. Nat Commun. 2020 May 13;11(1):2379.

3.Xiong X, Kuang H, Ansari S, Liu T, Gong J, Wang S, Zhao XY et al. Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis. Mol Cell. 2019 Aug 8;75(3):644-660.e5

4.Zhao XY, Xiong X, Liu T, Mi L, Peng X, Rui C, Guo L, Li S, Lin JD. Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nat Commun. 2018 Jul 30;9(1):2986. doi: 10.1038/s41467-018-05383-2.

5.Zhao XY, Li S, DelProposto JL, Liu T, Mi L, Porsche C, Peng X, Lumeng CN, Lin JD. The long noncoding RNA Blnc1 orchestrates homeostatic adipose tissue remodeling to preserve metabolic health. Mol Metab. 2018 Jun 8. pii: S2212-8778(18)30490-3

6.Li S, Mi L, Yu L, Yu Q, Liu T, Wang GX, Zhao XY, Wu J, Lin JD. Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7111-E7120.

7.Chen Z, Wang GX, Ma SL, Jung DY, Ha H, Altamimi T, Zhao XY, Guo L, Zhang P, Hu CR, Cheng JX, Lopaschuk GD, Kim JK, Lin JD. Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders. Mol Metab. 2017 Jun 21;6(8):863-872.

8.Mi L, Zhao XY, Li S, Yang G, Lin JD. Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation. Mol Metab. 2016 Nov;6(1):101-110.

9.Wang GX#, Zhao XY#, Meng ZX, Kern Matthias, Dietrich Arne, Chen ZM, et al. The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuating hepatic lipogenesis. Nat Med. 2014 Dec;20(12):1436-43.

10.Zhao XY, Li S, Wang GX, Yu Q, Lin JD. A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation. Mol Cell. 2014 Aug 7;55(3):372-82.