Name: Zhou Binbing

Title： K. C. Wong Chair Professor

Email: zhoubinbing@scmc.com.cn

Research Interests

Research on tumor drug resistance mechanism and new drug development to overcome drug resistance.

Ten Selected Papers

*co-corresponding authors; #co-first authors

1.Yang, F.#, Brady, S.W.#, Tang, C.#, Sun, H. #, Du,   L.#,  Barz, M., Ma, X., Chen, Y., Fang, H., Li, X., Kolekar, P., Pathak, O., Cai, J., Ding, L., Wang, T., von Stackelberg, A., Shen, S., Eckert, C., Klco, J. M., Chen, H., Duan, C., Liu, Y., Li, H., Li, B., Kirschner-Schwabe, R.*, Zhang, J.*, Zhou, B.-B.*. Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse. Nature Cancer, 2021, in press.

2.Li, B.#, Brady, S.W.#, Ma, X.#, Shen, S.#, Zhang, Y.#, Li, Y.#, Szlachta, K., Dong, L., Liu, Y., Yang, F., Wang, N., Flasch, D.A., Myers, M.A., Mulder, M.A., Ding, L., Liu, Y., Tian, L., Hagiwara, K., Xu, K., Zhou, X., Sioson, E., Wang, T., Yang, L., Zhao, J., Zhang, H., Shao, Y., Sun, H., Sun, L., Cai, J., Sun, H., Lin, T., Du, L., Li, H., Rusch, M., Edmonson, M.N., Easton, J., Zhu, X., Zhang, J., Cheng, C., Raphael, B.J., Tang, J., Downing, J.R., Alexandrov, L.B., Zhou, B.-B.*, Pui, C.*, Yang, J.J.*, Zhang, J.*. Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia. Blood, 2020 Jan 2; 135 (1): 41-55.

3..Chen,Y.#, Tang, C.#, Zhang, M.#, Huang, W., Xu, Y., Sun, H., Yang, F., Song, L., Wang, H., Mu,L., Li, M., Zheng, W., Miao, Y., Ding, L., Li, B., Shen,S., Liu, S., Li, H., Zhu, Z., Chen,H., Tang,Z., Chen,J., Hong, D., Chen,H.*,  Duan C.*,  Zhou, B.-B.*. Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia. Leukemia, 2019 Oct; 33(10): 2365-2378.

4..Du, L.#, Yang, F.#*, Fang, H., Sun, H., Chen, Y., Xu, Y., Li, H., Zheng, L., Zhou, B.-B.*.  AICAr suppresses cell proliferation by inducing NTP and dNTP pool imbalances in acute lymphoblastic leukemia cells. FASEB J., 2019 Mar; 33(3): 4525-4537.

5.Wang, D.#, Chen, Y.#, Fang, H., Zheng, L., Li, Y., Yang, F., Xu, Y., Du, L., Zhou B.-B*, Li, H.*.  Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5-Fluorouracil. J Cell Mol Med，2018 Dec; 22(12): 6202-6212.

6.Tang, C., Li, M., Chen, Y., Sun, H., Liu, S., Zheng, W., Zhang, M., Li, H., Fu, W., Zhang, W., Liang, A., Tang, Z., Hong, D., Zhou B.-B.*，Duan, C.*. Chemotherapy-induced niche perturbs hematopoietic reconstitution in B-cell acute lymphoblastic leukemia. J Exp Clin Cancer Res，2018 Aug 29; 37(1): 204.

7..Li, B.#, Li, H.#, Bai, Y.#, Kirschner-Schwabe, R., Yang, J., Chen, Y., Lu, G., Tzoneva, G., Ma, X., Wu, T., Li, W., Lu, H., Ding, L., Liang, H., Huang, X., Yang, M., Jin, L., Kang, H., Chen, S., Du, A., Shen, S., Ding, J., Chen, H., Chen, J., von Stackelberg, A., Gu, L., Zhang, J., Ferrando, A. *, Tang, J.*, Wang, S.*, Zhou, B.-B.*. Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL. Nat Med, 2015 Jun; 21(6): 563-571. (cover story)

8..Zhou, B.-B.*, Peyton, M., He, B., Liu, C., Girard, L., Caudler, E., Lo, Y., Baribaud, F.,  Mikami, I., Reguart, N., Yang, G., Yao, W., Vaddi, K., Gazdar, A., Friedman, S., Jablons, D., S., Newton, R., Fridman, J., Minna, J, Scherle, P. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell, 2006 Jul; 10(1): 39-50. (cover story)

9.Zhou, B.-B. and Elledge, S. J. The DNA damage response: putting checkpoints in perspective. Nature, 2000 Nov 23; 408, 433-439.