Jinke Cheng, Professor

Email: jkcheng@shsmu.edu.cn

Tel: 86-21-54661525

Research Interests

The research in Dr. Cheng’s laboratory mainly focuses on understanding the protein de-SUMOylation process mediated by SUMO-specific proteases (SENPs). They are particularly interested in determining the role of SENPs in regulation of inflammation and metabolism, and the mechanism underlying SENP regulation of these processes.

Ten Selected Papers (*co-corresponding authors; #co-first authors)

1. Cheng J, Pekins ND, Yeh ETH. Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases.Journal of Biological Chemistry.2005, 280:14492-14498.

2. Cheng J, Kang X, Zhang S and Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1α during hypoxia. Cell.2007, 131:584-595.

3. Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J *, Yeh ET*. SUMO-specific protease 2 is essential for suppression of polycomb group proteins mediated gene silencing during embryonic development, Molecular Cell. 2010, 38: 191-201.

4. Kang X, Li J, Zou Y, Yi J, Zhang H, Cao M, Yeh ET, Cheng J. PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia. Oncogene.2010, 29:5568-5578.

5. Cai R, Yu T, Huang C, Xia X, Liu X, Gu J, Xue S, Yeh ET, Cheng J. SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α. J Biol Chem. 2012, 287: 44464-44470.

6. Wang Q, Xia N, Li T, Xu Y, Zou Y, Zuo Y, Fan Q, Bawa-Khalfe T, Yeh ET, Cheng J. SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene.2013, 32: 2493-2498.

7. Liu B, Wang T, Mei W, Li D, Cai R, Zuo Y, Cheng J. SUMO-Specific Protease 1 De-SUMOylates Sharp-1 and Controls Adipocyte Differentiation. J Biol Chem. 2014, 289: 22358-22364.

8. Xiao N, Li H, Mei W, Cheng J. SUMOylation Attenuates Human β-arrestin 2 Inhibition of IL-1R-TRAF6 Signaling. J Biol Chem.2015, 290: 1927-35.

9. Wang YP, Zhou W, Wang J, Huang X, Zuo Y, Wang TS, Gao X, Xu YY, Zou SW, Liu YB, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer. Mol Cell.2016, 64: 673-687.

10. Cai J, Zuo Y, Wang T, Cao Y, Cai R, Chen FL, Cheng J*, Mu J*. A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity. Oncogene. 2016, 35:4949-4956.