Name: Michal Baniyash

Title： Full Professor

Email: michalb@ekmd.huji.ac.il

Tel: 972-507209754

Research Interests

Chronic inflammation and associated complications.

(i) Effects on tumor growth, immunotherapies, microbiota and inflammatory bowel diseases associated with colon cancer, chronic infectious diseases and ensuing inflammatory bone loss.

(ii) Developing modalities for early detection of such complications and combating the key players.

(iii) Using mouse models and cellular and molecular immunology techniques.

(iv) Translational studies for human diseases.

Ten Selected Papers

*co-corresponding authors; #co-first authors

1) Bronstein-Sitton N., Cohen-Daniel L., Vaknin I., Ezernitchi AV., Leshem B., Halabi A., Houri-Hadad Y., Greenbaum E., Zakay-Rones Z.C, Shapira L.C, and Baniyash M. (2003) Sustained exposure to bacterial antigen induces IFNg-dependent T cell antigen receptor z down-regulation and impaired T cell function. Nat. Immunol. 4:957-964.

2) Vaknin, I., Blinder. L., Wang, L., Gazit, R., Shapira, E., Genina, O., Pines, M., Pikarsky, E., Baniyash, M. (2008) A common pathway mediated through Toll-like receptors leads to T- and natural killer-cell immunosuppression. Blood. 111:1437-47.

3) Sade-Feldman, M., Kanterman, J., Ish-Shalom, E., Elnekave, M., Horwitz, E., and Baniyash, M. (2013) TNFa blocks differentiation and enhances suppressive activity of immature myeloid cells during chronic inflammation. Immunity. 38:541-54.

4) Klieger, Y., Almogi-Hazan, O., Ish-Shalom, E., Pato, A., Pauker, MH., Barda-Saad, M., Wang L., and Baniyash, M. (2014) Unique z-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation. Eur J Immunol. 44:58-68.

5) Kanterman, J., Sade-Feldman, M., Biton, M., Lasry, A., Ish-Shalom, E., Hubert, A., and Baniyash, M. (2014) Adverse Immunoregulatory Effects of 5FU and CPT11 Chemotherapy on Myeloid-Derived Suppressor Cells and Colorectal Cancer Outcomes. Cancer Res. 74:6022-6035.

6) Eldor, R., Klieger, Y., Sade-Feldman, M., Vaknin, V., Varfolomeev, I., Fuchs, F., and Baniyash, M . (2015) CD247, a Novel T-Cell Derived Diagnostic and Prognostic Biomarker for Detecting Disease Progression and Severity in Patients With Type 2 Diabetes Mellitus. Diabetes Care 38:113-8.  

7) Ish-Shalom, E., Meirow, Y., Sade-Feldman, M., Kanterman, J., Wang, L., Mizrahi, O., Klieger, Y., and Baniyash, M. (2016) Impaired SNX9 Expression in Immune Cells during Chronic Inflammation: Prognostic and Diagnostic Implications. J Immunol. 196:156-67.

8) Sade-Feldman, M., Kanterman, J., Keliger, Y., Ish-Shalom, E., Mizrahi, O., Saragovi, A., Shtainberg, H., Lotem, M., and Baniyash, M. (2016) Clinical significance of circulating CD33+CD11b+HLA-DR- myeloid cells in Stage-IV melanoma patients treated with ipilimumab. Clin Cancer Res, 65:857-67.

9) Meirow Y., and Baniyash M. (2017) Immune biomarkers for chronic inflammation related complications in non-cancerous and cancerous diseases. Cancer Immunol Immunother. 66:1089-1101.

10) Ben-Meir K, Twaik N, Baniyash M. (2018) Plasticity and biological diversity of myeloid derived suppressor cells. Curr Opin Immunol. 51:154-161.