Name: Rami AqeilanTitle： professor

Email: ramiaq@mail.huji.ac.il

Tel: +972-2-6758609

Research Interests

Role of Tumor Suppressor Gene Products of Common Fragile Sites in Human Diseases.

Ten Selected Papers

*co-corresponding authors; #co-first authors

1.Abu-Odeh, M., Salah, Z., Herbel, C., Hofmann, T. G., and Aqeilan, RI. WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response. PNAS, 2014 Nov 4; 111, E4716-4725.

2.Del Mare, S., Husanie, H., Iancu, O., Abu-Odeh, M., Evangelou, K., Lovat, F., Volinia, S., Gordon, J., Amir, G., Stein, J., Stein, G. S., Croce, C. M., Gorgoulis, V., Lian, J. B., and Aqeilan, RI. WWOX and p53 dysregulation synergize to drive the development of osteosarcoma. Cancer Res, 2016 Oct 15; 76, 6107-6117.

3.Hazan, I., Hofmann, T. G., and Aqeilan, RI. Tumor suppressor genes within common fragile sites are active players in the DNA damage response. PLoS Genet, 2016 Dec 15; 12, e1006436.

4.Abu-Remaileh M, Khalaileh A, Pikarsky E, Aqeilan RI. WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia. Cell Death Dis. 2018 May 1; 9(5): 511.

5.Abdeen SK, Ben-David U, Shweiki A, Maly B, Aqeilan RI. Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer. Cell Death Dis. 2018 Aug 6; 9(8):832.

6.Khawaled S., Suh S-S, Abdeen SK, Monin J, Distefano R, Nigita G, Croce CM and Aqeilan RI. WWOX inhibits metastasis of triple-negative breast cancer cells via modulation of microRNAs. Cancer Res, 2019 Apr 15; 79(8): 1784-1798.

7.Hazan I, Monin J, Bouwman BAM, Crosetto N, Aqeilan RI. Activation of oncogenic super-enhancers is coupled with DNA repair by RAD51. Cell Rep. 2019 Oct 15; 29(3): 560-572.e4.