Lab Leader: Bin Guo

Lab Name: Laboratory of Organelle Stress and Tissue Regeneration

Lab nfoI：Our lab is mainly interested in the function and underlying mechanisms of organelle stress in disease occurrence and tissue regeneration. The well-established research systems include mouse and human hematopoietic stem cell maintenance, leukemia stem cell and leukemogenesis. We focus on the following scientific questions: How mitochondrial stress is involved in hematopoietic regeneration and leukemogenesis? What’s the relation between ER stress and cell fate determination of hematopoietic stem cells? Does nucleolus stress response pathway play some role in hematopoietic stem cell homeostasis? Screening for small molecule drugs of human hematopoietic stem cell ex vivo expansion. Our studies will facilitate the development of efficient approaches to treat malignant or non-malignant blood diseases.

Lab Members: