姓名：Kassegne Kokouvi         

性别: 男             

出生年月：1982年6月            

国籍：多哥           

学位/学历：博士                 

职称：讲师

电子邮件：kassegnek@sjtu.edu   

办公地址：上海2000025，黄浦区重庆南路280号西1号楼       

办公电话：(021)63846590*776974

教育经历

2008年9 月 至 2013年12月       浙江大学 ，中国            病原生物学         博士

2005年9月 至 2006年7月           洛美大学，多哥             生命科学           硕士

2002年9月 至 2005年7月         洛美大学，多哥             自然科学           本科

工作经历

2020年12月 至 现在              欧洲杯竞猜平台，中国                       助理教授

2019年4月 至 2020年11月       江南大学 ，中国                                 博士后

2015年10月 至 2018年12月      中国疾病预防控制中心寄生虫病预防控制所      博士后

2014年1月 - 2014年12月         浙江大学 ，中国                                  研究助理工作 （志愿者）

社会/学术任职和活动

10多个学术会议演讲邀请

在多哥、加纳、尼日利亚进行疟疾流行病学研究

审稿人员，Frontiers in Immunology

编委会成员, Molecular   Biology & Nanomedicine.

研究方向/主要研究内容

感染与宿主免疫，分子监测

   利用免疫学、遗传学和高通量工具控制和预防疟疾。

      蜱传疾病的分子监测。

科研/教学研究项目

项目参与者/课题组成员：

2012年1月至2015年12月：钩端螺旋体对不同宿主与细胞致病性差异及其播散与排菌分子机制研究，   项目编号：81171534，国家自然科学基金项目。

2017年1月至2019年：重要热带病相关入侵 媒介生物及其病原的动态分布与资源库建设，项目编号：2016YFC1202000、 2016YFC1202003，国家重点研发计划项目。

项目主要研究者：

2019年3月 至 2020年11月： “Genome-wide   identification of immune selection related-antigen genes in Plasmodium    

falciparum Togo isolates”, 项目编号：1285210162190530， 江南大学。

2021年4月 至 2021年12月： “Molecular survey   of malaria infections and humoral immune responses to malaria blood-stage molecules in Togo subjects”   ，项目编号：，欧洲杯竞猜平台。

主要学术成果

期刊论文

Kassegne K, Hu W, Ojcius DM, Sun D, Ge Y,   Zhao J, Yang XF, Li L, and Yan J (2013). Identification   of collagenase as a critical virulence factor for invasiveness and   transmission of pathogenic Leptospira species. J Infect Dis,   209(7):1105-15. doi: 10.1093/infdis/jit659.

Zhao JF, Tan PL, Wang ZJ, Hu WL, Yan J, and Kassegne   K* (2016). Collagenase activity and pathogenic mechanism of colA   gene product of Leptospira interrogans. Chinese Journal of Zoonoses,   31 (1). doi:   10.3969/j.issn.1002-2694.2016.01.002. (In Chinese)

Kassegne   K, Abe EM, Chen JH, and Zhou XN (2016). Immunomic approaches   for antigen discovery of human parasites. Expert Rev Proteomics,   13(12): 1091-1101. doi:10.1080/14789450.2016.1252675.

Chen SB, Wang   Y, Kassegne K, Xu B, Shen HM, and Chen JH   (2017). Whole-genome sequencing of                         a Plasmodium vivax clinical isolate exhibits geographical   characteristics and high genetic variation in China-Myanmar   border area. BMC Genomics, 18(1):131. doi:   10.1186/s12864-0173523-y.

Kassegne K, Zhang T, Chen SB, Xu   B, Dang ZS, Deng WP, Abe EM, Shen HM, Hu W, Guyo TG, Nwaka S, Chen JH, and Zhou XN (2017). Study   Roadmap for High-throughput Development of Easy to Use and Affordable   Biomarkers as Diagnostics for Tropical Diseases: A Focus on Malaria and   Schistosomiasis. Infect Dis Poverty, 6(1):130. doi:   10.1186/s40249-017-0344-9.

Abe   EM, Guan W, Guo YH, Kassegne K, Qin JQ, Xu J, Chen JH, Ekpo UF, Li SJ,   and Zhou XN (2018). Differentiating snail intermediate hosts of Schistosoma   spp. using molecular approaches: Fundamental to successful integrated control   mechanism in Africa. Infect Dis Poverty, 7(1):29. doi:10.1186/s40249-018-0401-z.

Shen HM, Chen SB, Cui YB, Xu B, Kassegne K, Abe EM,   Wang Y, and Chen JH (2018). Whole-genome sequencing and analysis of Plasmodium falciparum isolates   from China-Myanmar border area.  Infect Dis   Poverty, 13;7(1):118. doi: 10.1186/s40249-018-0493-5.

Kassegne K, Wang Y, Abe EM, Cui   YB, Chen SB, Xu B, Deng WP, Shen HM, Wang Y, Chen JH, and Zhou XN (2019).   Contribution of immunomics to malaria research: potential impact for serology   testing and surveillance. Expert Rev Proteomics, 16(2):117-129. doi: 10.1080/14789450.2019.1554441.

Agbana   YL, Ni Y, Zhou M, Zhang Q, Kassegne K, Karou SD, Kuang Y, and Zhu Y (2020). Garlic-derived   bioactive compound S-allylcysteine inhibits cancer progression through   diverse molecular mechanisms. Nutr Res, 73:1-14. doi:   10.1016/j.nutres.2019.11.002.

Uwase   J, Chu RL, Kassegne K, Lei Y,Shen F, Fu H, Sun Y, Xuan Y,   Cao J and Cheng Y (2020). Immunogenicity analysis of conserved fragments in Plasmodium   ovale merozoite surface protein 4. Malar   J, 19(1):126. doi:   10.1186/s12936-020-03207-7.

Lin K-M, Wang D-Q, Kassegne K, Wang JY, Shi F, Qian   YJ, Jin Q, Chen JF, Ma AX, Li Jun, Yang YC, Abilahi F, Mihayo M, Lu SN, Yang   F, Zhou XN and Li SJ (2020). A Novel Immunochromatographic   Test Strip Versus A Commercial Rapid Diagnostic Test for the Detection of   Imported Plasmodium Species in Guangxi Province, China: A Comparative   Evaluation. Research Square, doi: 10.21203/rs.3.rs-34430/v1.

Kassegne K*, Komi Koukoura   K, Shen HM, Chen SB, Fu HT, Chen YQ, Chen JH, Zhou XN and Cheng Y (2020).   Genome-wide analysis of the malaria parasite Plasmodium falciparum   isolates from Togo reveals selective signals in immune selection-related   antigen genes. Front Immunol, 11:552698. doi: 10.3389/fimmu.2020.552698.

Shen FH, Ong JJY, Sun YF, Lei Y, Chu RL, Kassegne K,   Fu HT, Jin C, Han ET, Russell B, Han JH, Cheng Y (2021). A chimeric Plasmodium   vivax Merozoite Surface Protein Antibody Recognises and Blocks   Erythrocytic P. cymology Berok Merozoites in vitro. Infect Immun, 89(2):   e00645-20.   doi: 10.1128/IAI.00645-20.

Shi   S-M, Shi T-Q, Chen S-B, Cui Y-B, Kassegne K, Okpeku M, Chen J-H and   Shen H-M (2021). Genome-Wide Scans for Ghanaian Plasmodium falciparum   Genes Under Selection from Local and Chinese Host Populations. Front Cell   Infect Microbiol, 11:630797. doi: 10.3389/fcimb.2021.630797.

学术会议

Kassegne, Kokouvi; WHO-ANDI   Demonstration Project: ‘‘Development of easy to use and affordable biomarkers   as diagnostics for Types II & III diseases’’. The 2018 Annual   Conference of the Chinese Society of Preventive Medicine. Beijing, China,   2018.8.16.

Kassegne, Kokouvi; Chen,   Jun-Hu; High-Throughput   Screening Assays for the Development of Malaria Surveillance Tools. The 4^th   Symposium on Surveillance Response System Leading to Tropical Diseases   Elimination. Shanghai, Shanghai, 2018.6.26至2018.6.27.

Kassegne, Kokouvi; Chen,   Jun-Hu; High-Throughput   Screening Platform for the Discovery of Malaria Blood-Stage Molecules. Queenstown   Molecular Biology Annual Meetings – Drug Discovery and Societal Impact in   Conjunction with the 10^th National Forum on New Technologies in   Drug Discovery and the 7^th Meeting of Chinese Network for Drugs   and Diagnostics Innovation. Shanghai, China, 2018.3.22至2018.03.23.

Kassegne, Kokouvi;   Round   table discussion on The Responsibilities   and Obligations of Young Leaders in Global Health of “Young Generation   Leaders in Global Health” Round Table Conference. Belt and road High   level Meeting for Health Cooperation – Toward a Health Silk Road. Beijing, China,   2017.8.17至2017.8.19.

Kassegne, Kokouvi; New Technologies for   the Development of Diagnostic Tools and Vaccines for Human Parasites. BIT’s   9^th World Congress of Vaccine: New Technologies, New Vaccines.   Beijing, China, 2017.3.29至2017-3-31.

Kassegne, Kokouvi; Chen,   Jun-Hu;   High-Throughput Screening Assays for the Development of Malaria Surveillance   Tools. Queenstown Molecular Biology Annual Meetings – Drug   Discovery and Basics Science in Conjunction with the 9^th National   Forum on New Technologies in Drug Discovery and the 6^th Meeting of   Chinese Network for Drugs and Diagnostics Innovation. Shanghai, China,   2017.3.16至2017.3.17.

著作

Kassegne K and Chen JH (2019). Immunoproteomic Platform for Antigen Screening of   Human Parasitic Infections for Serodiagnostic and Vaccine Development. In   book: Tropical Diseases in China: Neglected Tropical Diseases and   Malaria. Edition: Public Health In China Series, Ed. Li LM. Chap: 3.   People's Medical Publishing House, 172-182.

荣誉及奖项

2007年7月：博士学奖学金，中国留学基金管理委员会

2012年6月：博士论文优等奖 ‘Summa Cum Laude’，浙江大学

2018年8月：青年优秀报告奖，中华预防医学会全球卫生分会，中国疾病预防控制中心寄生虫病预防控制所

2019年11月：公共卫生研究中心科研项目启动基金，江南大学

2021年3月：青年教师科研项目启动基金，欧洲杯竞猜平台

Profile

Name：Kassegne Kokouvi        

Gender:   Male                  

Date   of birth：June 1982             

Native   Place：Togo            

Degree：PhD                   

Title:   Assistant   Professor, Lecturer           

Email：kassegnek@sjtu.edu.cn     

Address：Building 1, 280   South Chongqing Road, Shanghai 2000025              

Office   Tel：(021)63846590*776974

Education

Sept. 2002 To   Jul. 2005       University of Lomé,   Togo        Natural   Sciences                 BSc              

Sept. 2005 To   Jul. 2006       University of Lomé,   Togo       Life Sciences   (distinction)       MSc       

Sept. 2008 To   Dec. 2013      Zhejiang University,   China      Pathogenic Organisms             PhD      

Appointments

Dec. 2020   To Present      Lecturer/Assist.   Professor,   Shanghai   Jiao Tong University School of Medicine, China

Apr.   2019 To Nov. 2020    Postdoctoral Research Fellow,   School of Medicine, Jiangnan University, China

Oct.   2015 To Dec. 2018    Postdoctoral Research Fellow,   National Institute of Parasitic Diseases (NIPD), China CDC

Jan.   2014 To Dec. 2014    Junior Research Fellow (volunteerism),   School of Medicine, Zhejiang University, China

Academic   Participation and Activities

Selected   measures of academic esteem

I have received and   accepted more than 10 invitations to speak sessions.

International agencies

My scientific advice was   requested by the NIPD, China CDC by being an investigator for The United Nations   Office for Project Services-funded WHA-WHO demonstration project “Development   for Easy to Use and Affordable Biomarkers as Diagnostics for Types II and III   Diseases”, from 2016-2017.

I lead epidemiological studies   on malaria in African countries in collaboration with the following   institutions:

      University of Lomé, Togo

      University of Lagos   and Akanu Ibiam Federal Polytechnic, Nigeria

      University of Health   and Allied Sciences, Ghana

My scientific advice was requested by the NIPD,   China CDC by having served   as facilitator and instructor on tropical diseases research themes,   especially on malaria surveillance and control to fellows from the following institutions:

        Kenya Medical Research Institute (KEMRI), Kenya

        Theodor Bilharz Research Institute (TBRI), Egypt

        University of Lagos, Nigeria

        University of Health and Allied Sciences, Ghana

        Central Public Health Laboratory (CPHL), Papua New Guinea

        University of Papua New Guinea, Papua New Guinea

        Papua New Guinea Institute of Medical Research (PNGIMR), Papua New Guinea

Academic   journals

I   serve as Editorial Board Member for Molecular   Biology & Nanomedicine and   contribute in peer-reviewing articles for Frontiers in Immunology

Research   interest

Infection   and Host Immunity, Molecular Surveillance

My   primary   research interest focuses in the use of   immunologic, genetic, and high-throughput tools for the control and   prevention of malaria in advancing:

     Understanding of humoral immune   responses to malaria antigens for correlates of clinical immunity.     

     Knowledge on pathogen-host   interactions and the roles protein expression plays in malaria severity.

     Proteogenomic research to   understand structural variations of malaria blood-stage molecules in   functional complexes.

My   research interests also expand to molecular surveillance of relapsing fever Borrelia,   and other tick-borne diseases.

Projects

I have been participant/member of   research group awarded for the following projects:

       Jan. 2012 To Dec. 2015: ‘Pathogenicity of Leptospira to different   hosts and cells and molecular mechanism of its     

     dissemination and excretion’, Grant   No. 81171534, National Natural   Science Foundation of China.

     Jan. 2017 To   Dec. 2019: ‘Dynamic distribution of important tropical disease related   invasive vectors and their       

pathogens and construction of resource   base’, Grant No. 2016YFC1202000 and 2016YFC1202003,   National Key

Research   and Development Program of China.

Principal Investigator   for the following projects:

    Apr. 2019 To Nov.   2020: Genome-wide identification of immune selection related-antigen genes in   Plasmodium   

    falciparum Togo   isolates,   Grant No. 1285210162190530, Jiangnan University.

Mar.   2021 To Dec. 2023: Molecular survey of malaria infections and humoral immune   responses to malaria blood-stage

molecules in Togo subjects. Grant No., Shanghai Jiao Ton University.

Publications

Kassegne K, Hu W, Ojcius DM, Sun D, Ge Y,   Zhao J, Yang XF, Li L, and Yan J (2013). Identification   of collagenase as a critical virulence factor for invasiveness and   transmission of pathogenic Leptospira species. J Infect Dis,   209(7):1105-15. doi: 10.1093/infdis/jit659.

Zhao JF, Tan PL, Wang ZJ, Hu WL, Yan J, and Kassegne   K* (2016). Collagenase activity and pathogenic mechanism of colA   gene product of Leptospira interrogans. Chinese Journal of Zoonoses,   31 (1). doi:   10.3969/j.issn.1002-2694.2016.01.002. (In Chinese)

Kassegne   K, Abe EM, Chen JH, and Zhou XN (2016). Immunomic approaches   for antigen discovery of human parasites. Expert Rev Proteomics,   13(12): 1091-1101. doi:10.1080/14789450.2016.1252675.

Chen SB, Wang   Y, Kassegne K, Xu B, Shen HM, and Chen JH   (2017). Whole-genome sequencing of                         a Plasmodium vivax clinical isolate exhibits geographical   characteristics and high genetic variation in China-Myanmar   border area. BMC Genomics, 18(1):131. doi:   10.1186/s12864-0173523-y.

Kassegne K, Zhang T, Chen SB, Xu   B, Dang ZS, Deng WP, Abe EM, Shen HM, Hu W, Guyo TG, Nwaka S, Chen JH, and Zhou XN (2017). Study   Roadmap for High-throughput Development of Easy to Use and Affordable   Biomarkers as Diagnostics for Tropical Diseases: A Focus on Malaria and   Schistosomiasis. Infect Dis Poverty, 6(1):130. doi:   10.1186/s40249-017-0344-9.

Abe EM, Guan W, Guo YH, Kassegne K, Qin JQ, Xu J,   Chen JH, Ekpo UF, Li SJ, and Zhou XN (2018). Differentiating snail   intermediate hosts of Schistosoma spp. using molecular approaches: Fundamental   to successful integrated control mechanism in Africa. Infect   Dis Poverty, 7(1):29.   doi:10.1186/s40249-018-0401-z.

Shen HM, Chen SB, Cui YB, Xu B, Kassegne K, Abe EM,   Wang Y, and Chen JH (2018). Whole-genome sequencing and analysis of Plasmodium falciparum isolates   from China-Myanmar border area.  Infect Dis   Poverty, 13;7(1):118. doi: 10.1186/s40249-018-0493-5.

Kassegne K, Wang Y, Abe EM, Cui   YB, Chen SB, Xu B, Deng WP, Shen HM, Wang Y, Chen JH, and Zhou XN (2019).   Contribution of immunomics to malaria research: potential impact for serology   testing and surveillance. Expert Rev Proteomics, 16(2):117-129. doi: 10.1080/14789450.2019.1554441.

Agbana   YL, Ni Y, Zhou M, Zhang Q, Kassegne K, Karou SD, Kuang Y, and Zhu Y (2020). Garlic-derived   bioactive compound S-allylcysteine inhibits cancer progression through   diverse molecular mechanisms. Nutr Res, 73:1-14. doi:   10.1016/j.nutres.2019.11.002.

Uwase   J, Chu RL, Kassegne K, Lei Y,Shen F, Fu H, Sun Y, Xuan Y,   Cao J and Cheng Y (2020). Immunogenicity analysis of conserved fragments in Plasmodium   ovale merozoite surface protein 4. Malar   J, 19(1):126. doi:   10.1186/s12936-020-03207-7.

Lin K-M, Wang D-Q, Kassegne K, Wang JY, Shi F, Qian   YJ, Jin Q, Chen JF, Ma AX, Li Jun, Yang YC, Abilahi F, Mihayo M, Lu SN, Yang   F, Zhou XN and Li SJ (2020). A Novel Immunochromatographic   Test Strip Versus A Commercial Rapid Diagnostic Test for the Detection of   Imported Plasmodium Species in Guangxi Province, China: A Comparative   Evaluation. Research Square, doi: 10.21203/rs.3.rs-34430/v1.

Kassegne K*, Komi Koukoura   K, Shen HM, Chen SB, Fu HT, Chen YQ, Chen JH, Zhou XN and Cheng Y (2020).   Genome-wide analysis of the malaria parasite Plasmodium falciparum   isolates from Togo reveals selective signals in immune selection-related   antigen genes. Front Immunol, 11:552698. doi: 10.3389/fimmu.2020.552698.

Shen FH, Ong JJY, Sun YF, Lei Y, Chu RL, Kassegne K,   Fu HT, Jin C, Han ET, Russell B, Han JH, Cheng Y (2021). A chimeric Plasmodium   vivax Merozoite Surface Protein Antibody Recognises and Blocks   Erythrocytic P. cymology Berok Merozoites in vitro. Infect Immun, 89(2):   e00645-20.   doi: 10.1128/IAI.00645-20.

Shi   S-M, Shi T-Q, Chen S-B, Cui Y-B, Kassegne K, Okpeku M, Chen J-H and   Shen H-M (2021). Genome-Wide Scans for Ghanaian Plasmodium falciparum   Genes Under Selection from Local and Chinese Host Populations. Front Cell   Infect Microbiol, 11:630797. doi: 10.3389/fcimb.2021.630797.

Conferences

Kassegne K. WHO-ANDI   Demonstration Project: ‘‘Development of easy to use and affordable biomarkers   as diagnostics for Types II & III diseases’’. The 2018 Annual   Conference of the Chinese Society of Preventive Medicine. Beijing, China,   August 16, 2018.

Kassegne K and   Chen JH. High-Throughput Screening Assays for the Development of Malaria   Surveillance Tools. The 4^th Symposium on Surveillance Response   System Leading to Tropical Diseases Elimination. Shanghai, China, June   26-27, 2018.

Kassegne K,   et al. High-Throughput Screening Platform for the Discovery of Malaria   Blood-Stage Molecules. Queenstown Molecular Biology Annual Meetings – Drug   Discovery and Societal Impact in Conjunction with the 10^th   National Forum on New Technologies in Drug Discovery and the 7^th   Meeting of Chinese Network for Drugs and Diagnostics Innovation.   Shanghai, China, March 22-23, 2018.

Kassegne K. Round table discussion on The   Responsibilities and Obligations of Young Leaders   in Global Health of “Young Generation Leaders in Global   Health” Round Table Conference. Belt and road High level Meeting   for Health Cooperation – Toward a Health   Silk Road. Beijing, China, August 17-19, 2017.

Kassegne K. New   Technologies for the Development of Diagnostic Tools and Vaccines for Human   Parasites. BIT’s 9^th World Congress of Vaccine: New   Technologies, New Vaccines. Beijing, China, March 29-31, 2017.

Books/Monographs

Kassegne   K and   Chen JH (2019). Immunoproteomic Platform for   Antigen Screening of Human Parasitic Infections for Serodiagnostic and   Vaccine Development. In book: Tropical Diseases in China: Neglected   Tropical Diseases and Malaria. Edition: Public Health In China Series,   Ed. Li LM. Chap: 3. People's Medical Publishing House, 172-182.

Honors   and Awards

Sep. 2007    PhD Scholarship, China   Scholarship Council (CSC)

Jun. 2012      Summa Cum Laude for the PhD thesis, Zhejiang University  

Aug.   2018   Excellent Youth   Academic Report, Chinese Preventive Medicine Association, Global Health Unit

I have been also awarded the following   prizes:    

Nov. 2019     Startup   Fund for Scientific Research Project of Public Health Research Centre,   Jiangnan University

Mar. 2021     Young Faculty Startup Fund for Scientific Research Project, Shanghai   Jiao Ton University

Lectures

I am responsible for   courses construction and lectures at both undergraduate and postgraduate   levels at Shanghai Jiao Tong University School of Medicine and the University   of Edinburg on modules pertaining to:

     Emerging   Infectious Diseases and Zoonotic Diseases

       Scientific Paradigms, Research Methods 

I am a college tutor and provide regular training/guidance   for postgraduate levels.

I am academic advisor having supervised   postgraduate student project placements.