I． Chair of the Department

Professor Kun Yin is currently leading the Department of Environmental Health and Ecological Security in School of Global Health, Shanghai Jiao Tong University School of Medicine, serving as the head of Environmental Health and Drug Resistance Control Research Group. Prof. Yin obtained a Ph.D. degree from the University of Chinese Academy of Sciences in 2016 and completed a postdoctoral fellowship at Ohio State University, University of Pennsylvania and University of Connecticut, respectively between 2016-2021. He presided over the development and research of a series of new, fast, ultra-sensitive, high-throughput analysis and diagnosis technologies and mobile Internet intelligent detection platform for infectious diseases. He has published more than 30 SCI papers and IEEE conference papers in total. Prof. Yin has worked at Chemical Engineering Journal (IF = 13.273), Theranostics (IF = 11.556), Water Research (IF = 11.236), Biosensors and Sensors Analytical Chemistry (IF = 6.986), Lab on a Chip (IF = 6.799) published 11 SCI papers as the first author in the first district journals of CAS. Among them, 6 papers with more than 10 influencing factors were cited more than 1000 times. In addition, Prof. Yin has published two academic monographs as the corresponding author and has been granted 8 Chinese invention patents. He has won honors such as "Special Award of President of Chinese Academy of Sciences" and "Excellent Doctoral Thesis of Chinese Academy of Sciences".

II． Department Introduction

The Department of Environmental Health and Ecological Security was established in 2021, and the chair is Professor Kun Yin. There are 3 full-time teaching staff, including 1 senior and 2 intermediate titles, with an average age of 30. In the past two years, the department has introduced many young talents from the University of Pennsylvania, Duke University, Fudan University and other well-known universities at home and abroad, forming a young, dynamic and internationally oriented research team. In response to the national call to strengthen biosafety construction, the Department of Environmental Health and Ecological Security mainly carries out biosafety risk prevention and control and management system construction at the human-environment interface, improves the national biosafety management capacity, and effectively protects the life and health safety of citizens. The main research directions are pathogen detection, antibiotic resistance prevention and control, etc. At present, the Department of Environmental Health and Ecological Security undertakes a number of national, ministerial, university-level research projects, with nearly 3 million research funds.

The department is responsible for the lesson of Introduction to Global Health and Total Health and the construction of several courses of the school, such as Environment, Climate Change and Biodiversity Conservation, Ecosystem Health, Food Systems and Sustainability, etc.

III． Key Researchers

Qinqin Hu, female, Lecturer/Research Assistant, Doctor of Engineering. Dr. Hu obtained a Ph.D. degree from College of Biosystems Engineering and Food Science, Zhejiang University in 2016, and completed postdoctoral training and worked as assistant researcher at Institutes of Biomedicine, Fudan University in 2021. In June 2021, she joined the Department of Environmental Health and Ecological Security, School of Global Health, Shanghai Jiao Tong University School of Medicine full-time. Dr. Hu conducts research in developing new optical sensors for rapid detection of harmful substances in food and environment, as well as screening functional nucleic acids for disease diagnosis and potential marker identification. So far, she has published more than 10 SCI papers, including 7 papers with a cumulative impact factor of >90; authorized or applied for 4 invention patents. Dr. Hu has presided over the General Program of the Postdoctoral Foundation, the Special Program of the Postdoctoral Foundation, the Youth Program of the National Natural Science Foundation of China, and the "Translational Medicine Open Project" of Shanghai Jiao Tong University.

Leshan Xiu, male, Lecturer/Research Assistant, Doctor of Medicine. Dr. Xiu obtained a Ph.D. degree from Peking Union Medical College, Tsinghua University in 2021, and joined the Department of Environmental Health and Ecological Security, School of Global Health, Shanghai Jiao Tong University School of Medicine full-time. Dr. Xiu conducts research in molecular methods for pathogen identification and AMR detection; combating infectious diseases and antimicrobial resistance using One Health approach; development of novel tools for disease diagnostics based on optical biosensors. So far, he has published 20 SCI papers, including 9 works, with a cumulative impact factor of >90. Dr. Xiu has been awarded "Beijing Outstanding Graduate", "National Scholarship for Doctoral Students", "National Scholarship for Master students".

IV． Major Research Achievements of the Department

1. Project funding

(1) Novel Coronavirus Multi-target visual diagnosis Method based on CRISPR/Cas recognition mechanism, 22104090, Youth Foundation of National Natural Science Foundation of China.

(2) Targeting regulation of GTF2H4 by Aptamer-DNA nanoassembly in ischemia-reperfusion injury and its mechanisms, 82000270, Youth Foundation of National Natural Science Foundation of China.

(3) Aptasensors with cascades amplification for diagnosis of TNBC exosomes, TMSK-2021-114, National Facility of Translational Medicine (Shanghai).

(4) Monitoring and control of wastewater resistance at human-animal-environment interface in Chongming Island,SGHKJCX20221-02,One Health Pilot Study on Chongming Island's.

(5) Research on on-site monitoring and early warning technology of Schistosoma japonicum based on environmental nucleic acid,NHCKFKT2021-06, Open Project Fund of Key Laboratory of Parasite And Vector Biology, NHC.

2. Selected Publications

(1) Yin Kun, Xiong Ding, Zhiheng Xu, Ziyue Li, Xingyu Wang, Hui Zhao, Clifford Otis, Baikun Li, Changchun Liu*. Multiplexed colorimetric detection of SARS-CoV-2 and other pathogens in wastewater on a 3D printed integrated microfluidic chip.Sensors and Actuators B: Chemical, 2021,130242. (IF=7.460)

(2) Yin Kun, Xiong Ding, Ziyue Li, Maroun M. Sfeir, Enrique Ballesteros, Changchun Liu*. Autonomous lab-on-paper for multiplexed, CRISPR-based diagnostics of SARS-CoV-2.Lab on a Chip,2021, (IF=6.799)

(3) Kun Yin,Xiong Ding, Ziyue Li, Hui Zhao,Kumarasen Cooper,Changchun Liu*. Dynamic aqueous multiphase reaction system for one-pot CRISPR-Cas12a based ultrasensitive and quantitative molecular diagnosis.Analytical Chemistry, 2020, 92:8561-8568. (IF= 6.986)

(4) Kun Yin, Vikram Pandian, Karteek Kadimisetty, Xin Zhang, Carlos Ruiz, Kumarasen Cooper, Changchun Liu*. Real-time colorimetric Quantitative Molecular Detection of infectious Diseases on Smartphone-based Diagnostic platform.Scientific Reports, 2020,10：1-9. (IF= 4.379)

(5) Kun Yin, Vikram Pandian, Karteek Kadimisetty, Carlos Ruiz, Kumarasen Cooper, Jianxin You, and Changchun Liu*. Synergistically enhanced colorimetric molecular detection using smart cup: a case for instrument-free HPV-associated cancer screening.Theranostics,2019, 9: 2637-2645.(IF= 11.556)

(6) Kun Yin, Qiaoning Wang, Min Lv, Lingxin Chen*. Microorganism remediation strategies towards heavy metals.Chemical Engineering Journal,2019, 360: 1553-1563. (IF= 13.273)

(7) Kun Yin, Min Lv, Qiaoning Wang; Yixuan Wu; Chunyang Liao*, Lingxin Chen. Simultaneous Bioremediation and Biodetection of Mercury Ion through Surface Display of Carboxylesterase E2 from Pseudomonas Aeruginosa PA1.Water Research,2016. 103: 383-390.(IF= 11.236)

(8) Kun Yin, Yixuan Wu, Shasha Wang and Lingxin Chen*. A sensitive fluorescent biosensor for the detection of copper ion inspired by biological recognition element pyoverdine.Sensors and Actuators B: Chemical,2016, 232: 257-263.(IF=7.460)

(9) Kun Yin, Fabiao Yu, Dongyan Liu, Zhihong Xie and Lingxin Chen*. Cyanine-based colorimetric and fluorescent probe for the selective detection of diethylstilbestrol in seawater, shrimp and fish samples.Sensors and Actuators B: Chemical,2016, 223: 799-805.(IF=7.460)

(10) Kun Yin, Fabiao Yu*, Weiwei Zhang, and Lingxin Chen*. A near-infrared ratiometric fluorescent probe for cysteine detection over glutathione indicating mitochondrial oxidative stress in vivo. Biosensors and Bioelectronics,2015, 74: 156-164.(IF=10.618)

(11) Kun Yin, Bowei Li, Xiaochun Wang, Weiwei Zhang* and Lingxin Chen*. Ultrasensitive colorimetric detection of Cu²⁺ ion based on catalyticoxidation of L-cysteine.Biosensors and Bioelectronics,2015, 64: 81-87.(IF=10.618)

(12) Kun Yin, Weiwei Zhang and Lingxin Chen*. Pyoverdine secreted by Pseudomonas aeruginosa as a biological recognition element for the fluorescent detection of furazolidone.Biosensors and Bioelectronics,2014, 51: 90-96. (IF=10.618)

(13) Kun Yin, Leming Sun, Zhen Fan, Huacan Lin, Yujian Huang, Scott Galster, Jeff, Kuret, Douglas Scharre, Mingjun Zhang*. Fluorescent peptide nanoparticles to monitor Aβ oligomers. IEEE-NANO, 2017 IEEE 17th International Conference on Nanotechnology,2017, 25-28.

(14) Zhiheng Xu,Kun Yin, Xiong Ding, Ziyue Li, Xuanhao Sun, Baikun Li, Rajesh V. Lalla, Robert Gross, and Changchun Liu.An integrated E-Tube cap for sample preparation, isothermal amplification and label-free electrochemical detection of DNA.Biosensors and Bioelectronics.2021,186:113306. (IF=10.618)

(15) Xiong Ding,Kun Yin, Ziyue Li, Maroun M. Sfeir, and Changchun Liu. Sensitive quantitative detection of SARS-CoV-2 in clinical samples using digital warm-start CRISPR assay.Biosensors and Bioelectronics.2021, 184: 113218. (IF=10.618)

(16) Karteek Kadimisetty,Kun Yin, Aoife M. Roche, Yanjie Yi, Frederic D. Bushman, Ronald G. Collman, Robert Gross, Liang Feng, and Changchun Liu. "An integrated self-powered 3D printed sample concentrator for highly sensitive molecular detection of HIV in whole blood at the point of care."Analyst 2021, 146: 3234-3241. (IF=3.978)

(17) Xiong Ding,Kun Yin, Ziyue Li, Rajesh V. Lalla, Enrique Ballesteros, Maroun M. Sfeir, Changchun Liu*. Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay.Nature Communications,2020, 11:1-10. (IF=11.800)

(18) Weiwei Zhang,Kun Yin, Bowei Li and Lingxin Chen*. A glutathione S-transferase from Proteus mirabilis involved in heavy metal resistance and its potential application in removal of Hg²⁺.Journal of Hazardous Materials,2013, 261: 646-652.(IF=9.038)

(19) Weiwei Zhang,Kun Yin and Lingxin Chen*. Bacteria-mediated bisphenol A degradation.Applied Microbiology and Biotechnology,2013, 97: 5681-5689.(IF=3.670)

(20) Huacan Lin,Kun Yin, Zhen Fan, Jianjie ma, Mingjun Zhang*. Integrating tea nanoparticle with short peptides to generate tunable hydrogel scaffolds for diabetic ulcer.IEEE-NANO, 2017 IEEE 17th International Conference on Nanotechnology

(21) Xiong Ding,Kun Yin, Ju Chen, Kepeng Wang,Changchun Liu*. A ribonuclease-dependent cleavable beacon primer triggering DNA amplification for single nucleotide mutation detection with ultrahigh sensitivity and selectivity.Chemical Communications. 2019;55(84):12623-6. (IF=6.164)

(22) Qinqin Hu^#; Hua Li^#; Lihua Wang; Hongzhou Gu*; Chunhai Fan*. “DNA Nanotechnology Enabled Drug Delivery systems.”Chemical Reviews 2019,119(10): 6459-6506. (IF=52.76)

(23) Qinqin Hu^#; Sheng Wang; Lihua Wang; Hongzhou Gu*; Chunhai Fan*. “DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides.”Advanced Healthcare Materials 2018,7, 1-19.(IF=7.367)

(24) Qinqin Hu^#; Ronghui Wang; Hong Wang; Michael F. Slavik; Yanbin Li*. “Selection of Acrylamide-Specific Aptamers by a Quartz Crystal Microbalance Combined SELEX Method and Their Application in Rapid and Specific Detection of Acrylamide.”Sensors and Actuators B: Chemical 2018,273, 220-227.(IF=7.1)

(25) Qinqin Hu^#; Yingchun Fu; Xiahong Xu; Zhaohui Qiao; Ronghui Wang;Ying Zhang; Yanbin Li*. “A Colorimetric Detection of Acrylamide in Potato Chips Based on Nucleohile-Initiated Thiol-Ene Michael Addition.”Analyst 2016,141, 1136-1143. (IF=3.978)

(26) Qinqin Hu^#; Xiahong Xu; Yingchun Fu; Yanbin Li*. “Rapid methods for Detecting Acrylamide in Thermally Processed Foods: A Review.”Food Control 2015,56, 135-146.(IF=4.258)

(27) Qinqin Hu^#; Xiahong Xu; Zhanming Li; Ying Zhang; Jianping Wang; Yingchun Fu; Yanbin Li*. “Detection of Acrylamide in Potato Chips Using a Fluorescent Sensing Method Based on Acrylamide Polymerization-Induced Distance Increase Between Quantum Dots.”Biosensors and Bioelectronics 2014, 54, 64-71.(IF=10.257)

(28) Qinqin Hu^#; Xiahong Xu; Zhanming Li; Ying Zhang; Yanbin Li*. “Rapid Detection of Acrylamide in Food Using a Fluorescent Sensing Method Based on Functional CdSe/ZnS Quantum Dots.” IEEE Sensors 2013, 414-417.(IF=3.073)

(29) Zongxuan^#, Tong;Qinqin Hu; Hongzhou Gu*. “Deoxyribozymes: Selection, Biosensing and Outlook.”Chemical Journal of Chinese Universities-Chinese 2020, 41 (11), 2345-2355. (IF=0.576)

(30) Xiu L, Li Y, Wang F, Zhang C, Li Y, Zeng Y, Yin Y,Peng J*. Multiplex High-Resolution Melting Assay for Simultaneous Identification of Molecular Markers Associated with Extended-Spectrum Cephalosporins and Azithromycin Resistance in Neisseria gonorrhoeae.J Mol Diagn. 2020, S1525-1578(20)30430-X(JCR: Q1, IF:5.560)

(31) Xiu L, Li Y, Zhang C, Li Y, Zeng Y, Wang F*,Peng J*. A molecular screening assay to identify Chlamydia trachomatis and distinguish new variants of C. trachomatis from wild-type.Microb Biotechnol, 2021, 14:668-676(JCR: Q1, IF:5.810)

(32) Xiu L, Binder RA, Alarja NA, Kochek K, Coleman KK, Than ST, Bailey ES, Bui VN, Toh T, Erdman DD, Grey GC*. A RT-PCR assay for the detection ofcoronaviruses from four genera.J Clin Virol. 2020,128:104391(JCR: Q3, IF:3.164)

(33) Xiu L, Yuan Q, Li Y, Zhang C, Tang L, Peng J*. Emergenceofceftriaxone-resistant Neisseria gonorrhoeaestrains harbouring a novel mosaic penA gene in China.J Antimicrob Chemother. 2020, 75(4):907-910(JCR: Q1, IF: 5.794)

(34) Xiu L, Zhang C, Li Y, Wang F, Peng J*. High-resolution meltinganalysis for rapid detection of the internationally spreading ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone. J Antimicrob Chemother. 2020, 75(1):106-109(JCR: Q1, IF: 5.794)

(35) Xiu L, Zhang C, Li Y, Wang F, Peng J*. Simultaneous detectionofeleven sexually transmitted agents using multiplexed PCR coupled with MALDI-TOF analysis.Infect Drug Resist. 2019, 12:2671-2682(JCR: Q2, IF: 4.001)

(36) Xiu L, Zhang C, Wu Z, Peng J*. Establishment andApplication of a Universal Coronavirus Screening Method using MALDI-TOF mass spectrometry. Front Microbiol. 2017, 8:1510(JCR: Q1, IF: 5.643)

(37) Zhang C^#, Song F^#,Xiu L^#, Liu Y, Yang J, Yao L*, Peng J*. Identification and characterization of a novel rodent bocavirus from different rodent speciesinChina.Emerg Microbes Infect. 2018, 7(1):48(Co-first author, JCR: Q1, IF: 7.161)

(38) Zhang C^#,Xiu L^#, Xiao Y, Xie Z*, Ren L*, Peng J*. Simultaneous DetectionofKey Bacterial Pathogens Related to Pneumonia and Meningitis Using Multiplex PCR Coupled With Mass Spectrometry.Front Cell Infect Microbiol. 2018, 8:107(Co-first author, JCR: Q1, IF: 5.290)

3. Patents

(1) A sample rapid method to the detection of L-cysteine (Lingxin Chen, Kun Yin, Weiwei Zhang. Patent number: 201310311246.6).

(2) A sample rapid method to the detection of Cu²⁺ (Lingxin Chen, Kun Yin, Weiwei Zhang. Patent number: 201310311639.7).

(3) A novel heptamethine cyanine compound and their application (Lingxin Chen, Kun Yin, Fabiao Yu, Weiwei Zhang, Hao Chen, Ping Liu. Patent number: 201410322590.X).

(4) A heptamethine cyanine compound and their application (Lingxin Chen, Kun Yin, Fabiao Yu, Weiwei Zhang, Hao Chen, Ping Liu. Patent number: 201410294697.8).

(5) A method based on pyoverdine to simple and rapid detection of Cu²⁺ (Lingxin Chen, Kun Yin, Baihui Chai, Fabiao Yu. Patent number: 201510275268.0).

(6) A method based on heptamethine cyanine compound to simple and rapid detection of Cu²⁺ (Lingxin Chen, Kun Yin, Baihui Chai, Fabiao Yu. Application number: 201510275221.4).

(7) Xiahong Xu, Qinqin Hu, Ying Zhang, Yanbin Li. A fluorescent method for the detection of acrylamide in thermally processed foods. ZL201310383303.1

(8) Yanbin Li, Qinqin Hu, Yingchun Fu, Xiahong Xu, Ying Zhang. A colorimetric approach for rapid detection of acrylamide in thermally processed foods. ZL201510528800.5

(9) Hongzhou Gu, Qinqin Hu, Zongxuan Tong, Yizhou Jiang, Zhimin Shao, Xiyu Liu, Liping Ge, Tong Fu. A method to concentrate and identify the molecular markers of disease. (No. 202110361337.5)

(10) Hongzhou Gu, Qinqin Hu, Zongxuan Tong, Yizhou Jiang, Zhimin Shao, Xiyu Liu, Liping Ge, Tong Fu. Selection of DNAzymes that specifically sense triple negative breast cancers. (No. 202110364792.0)

(11) Peng J,Xiu L, Sun L. A method and kit for detection and molecular typing of SARS-CoV-2.

(12) Peng J,Xiu L, Guo J. A molecular method for simultaneous detection and identification of 11 sexually transmitted infection pathogens.

(13) Peng J,Xiu L. A multiplex assay and kit for detection of AMR markers in Neisseria gonorrhoeae.

4. Awards and talents at all levels

Kun Yin, Shanghai overseas high-level talents, 2021.