Name: Yongzhang Zhu

Degree: Ph.D

Title: Associate Professor

Email: yzhzhu@sjtu.edu.cn

Office Address: No.412 room in laohong lou building

Office Tel: 021-63846590-776694

Education

1. 2002.09-2007.07 Tsinghua University & Peking Union Medical College, Genetics Ph.D

2. 1998.09-2002.07 YunNan University School of life science National biology base class

Appointments

1. 2007.09-2009.09  Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine  Postdoc

2. 2011.03-2017.07  Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine,  Associate Professor

3. 2014.11-2015.11  Veterinary School, Cornell University, Visiting Scholar

4. 2017.08-2019.07  Institute of Antibiotics, Huashan Hospital Affiliated to Fudan University,  Associate Professor

5. 2020.06-2020.11   Pathogen NGS sequencing platform of P3 lab, Guangzhou Customs District Technology Center,  Associate Professor

6. 2020.12-Present   School of Global Health, Shanghai Jiao Tong University School of Medicine,  Associate Professor

Supported Grants

1. Time： 2010.01-2012.12  Title： Virulence evolution mechanism of serovar icterohaemorrhagiae  virulent  and Virulence-attenuated strains in Pathogenic Leptospira Interrogans      Grant Number：30900051  Source： National Natural Science Foundation of China

2. Time：2010.11-2013.10 Title：Genomic and Proteomic-based novel approach for screening  vaccine antigens of Bordetella pertussis  Grant Number：BK2010158  Source：Provincial Natural Science Foundation

3. Time：2008.09-2010.08  Title： Comparative Genomics of Serovar Autumns hypervirulent and Attenuated strains in Pathogenic Leptospira Interrogans  Grant Number：20080430655   Source：Chinese Postdoctoral Science Foundation

Research Interest：Pathogen Genomics and AMR control

My Ph.D graduated from Peking Union Medical College, Tsinghua University, and now I are Associate Professor of Department of Animal Health and Food Safety, School of Global Health, School of Medicine, Shanghai Jiaotong University, my main research directions are the epidemiological and transmission patterns and molecular mechanisms of clinically significant drug-resistant genes at the crossing human-animal-environment interfaces. I was supported by the National Natural Science Youth Fund, the Provincial Natural Science Fund and the National Postdoctoral Fund, etc. In the past five years, I has published more than 20 SCI papers as the first author or corresponding author, including 9 articles in Q1 of JCR, with 9 articles with impact factor over 10 points and the cumulative impact factor over 120, including Emerging Microbes & infections, Infectious Disease of Poverty, Sci Total Environ, mSystems, international of Food Microbiology and PLOS NTD.

Selected Publications

1) Min Li, Haoran Zhang, Wengang Zhang, Ying Cao, Bingqing Sun, et al, Xiaokui Guo, Jun Shang*, Shixin Huang*,Zhu YZ *(corresponding author),One global disseminated 193 kb high-risk hybrid plasmid harboring tet(X4), mcr or blaNDM threatening public health. Sci Total Environ 2023 Mar 14;876:162807.

2) Chang C, Guo W, Yu X, Guo C, Zhou N, Guo X, Huang RL*, Li Q*, Zhu Y*(corresponding author).Engineered M13 phage as a novel therapeutic bionanomaterial for clinical applications: From tissue regeneration to cancer therapy. Mater Today Bio 2023 Mar 24;20:100612.

3) Chao Lv, Jun Shang, Wengang Zhang, Bingqing Sun, Min Li, Chaoyi Guo, Nan Zhou, Xiaokui Guo*, Shixin Huang*, Zhu YZ *(corresponding author). Dynamic antimicrobial resistant patterns of Escherichia coli from healthy poultry and swine over 10 years in Chongming Island, Shanghai. Infect Dis Poverty 2022 Sep 16;11(1):98.

4) Nan Zhou, Zile Cheng, Xiaoxi Zhang, Chao Lv, Chaoyi Guo, Haodong Liu, Ke Dong, Yan Zhang, Chang Liu, Yung-Fu Chang, Sheng Chen, Xiaokui Guo*, Xiao-Nong Zhou*, Min Li*,Zhu YZ *(corresponding author). Global antimicrobial resistance: a system-wide comprehensive investigation using the Global One Health Index. Infect Dis Poverty 2022 Aug 23;11(1):92.

5) Zhu Y , Shi L, Zeng Y, Piao D, Xie Y, Du J, Gao M, Gao W, Tian J, Yue J, Li M, Guo X, Yao Y, Kang Y. Key immunity characteristics of diverse stages of brucellosis in rural population from Inner Mongolia, China. Infect Dis Poverty 2022 Jun 4;11(1):63.

6)Hongye Wang, Dongshan Yan, Ya Li, Yanfei Gong, Yulin Mai, Bingxiang Li, Xiaoyong Zhu, Xinrui Wan, Liyun Xie, HuaKe Jiang, Min Zhang, Ming Sun*, Yufeng Yao*,Zhu YZ *(corresponding author). Clinical and antibody characteristics reveal diverse signatures of severe and non-severe SARS-CoV-2 patients. Infect Dis Poverty. 2022 Feb 2;11(1):15.

7)Tinghua Lia, Lin Lyua, Yan Zhang, Ke Donga, Qingtian Li*, Xiaokui Guo*, *(corresponding author). A newly isolated E. thailandicus strain d5B with exclusively antimicrobial activity against C. difficile might be a novel therapy for controlling CDI.  Genomics 2020 Sep 18;S0888-7543(20)30206-8.

8) Tinghua Li, Yan Zhang, Ke Dong, Chih-Jung Kuo, Chong Li, Yong-Qiang Zhu, Jinhong Qin, Qing-Tian Li, Yung-Fu Chang*, Xiaokui Guo*,Zhu YZ *(corresponding author). Isolation and Characterization of the Novel Phage JD032 and Global Transcriptomic Response during JD032 Infection of Clostridioides difficile Ribotype 078. mSystems 2020 May 5;5(3):e00017-20.

9) Cuicai Zhang, Jianmin Xu, Tinglan Zhang, Haiyan Qiu, Zhenpeng Li, Enmin Zhang, Shijun Li, Yung-Fu Chang, Xiaokui Guo*, Xiugao Jiang*, Zhu YZ*(corresponding author). Genetic Characteristics of Pathogenic Leptospira in wild small animals and livestock in Jiangxi Province, China, 2002-2015.   PLOS Neglected Tropical Diseases. June 24, 2019  10.1371/journal.pntd.0007513

10) Xu-ming Li, Yao-xia Kang1, Liang Lin, En-Hou Jia, Dong-Ri Piao, Hai Jiang, Cui-Cai Zhang, Jin He, Yung-Fu Chang*, Xiao-Kui Guo*,Zhu YZ*(corresponding author).Genomic Characterization Provides New Insights for Detailed Phage- Resistant Mechanism for Brucella abortus. Front. Microbiol, 03 May 2019.

11) Jiayu Wang, Zheng Teng, Wei Chu, Fanghao Fang, Xiaoqing Cui, Xiaokui Guo, Xi Zhang*, Bruce Thorley*, hu YZ *(corresponding author). The Emergence and Spread of One Coxsackievirus A16 Genogroup D Novel Recombinant Strain Causing a Clustering HFMD Outbreak in Shanghai, China, 2016.  Emerg Microbes Infect. 2018 Jul 18;7(1):131.

12) Jiayu Wang, Zheng Teng, Xiaoqing Cui, Chongshan Li, Hao Pan, Yaxu Zheng, Shenghua Mao, Yuying Yang, Limeng Wu, Xiaokui Guo*, Zhu YZ *(corresponding author). Epidemiological and Serological Surveillance of Hand-Foot-and-Mouth Disease in Shanghai, China, 2012- 2016.  Emerg Microbes Infect. 2018 Jan 24;7(1):8.

13) Zhang C, Yang H, et al, Chang YF, Guo X*,Zhu YZ *(co-corresponding author), Jiang X*. Molecular Typing of Pathogenic Leptospira Serogroup Icterohaemorrhagiae Strains Circulating in China during the Past 50 Years. PLoS Negl Trop Dis. 2015 May 19;9(5):e0003762.

14) Zeng LB, Zhuang XR, et al, Guo XK*,Zhu YZ *(corresponding author). Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants. J Proteomics. 2015 Jan 1; 112:27-37.

15) Zhu WN, Huang LL, et al,Zhu YZ *(co-corresponding author), Guo XK*. Isolation and characterization of two novel plasmids from pathogenic Leptospira interrogans serogroup Canicola Serovar Canicola strain Gui44. PLoS Negl Trop Dis. 2014 Aug 21;8(8):e3103 .

16) Huang L, et al, Guo XK, Qin JH,Zhu YZ *(corresponding author). Re-characterization of an extrachromosomal circular plasmid in the pathogenic Leptospira interrogans serovar Lai strain 56601. Acta Biochim Biophys Sin (Shanghai). 2014 Jul;46(7):605-11.