Dr. Qinqin Hu, PhD, Associate Professor

   2024 “Shanghai Youth Top Talent Program of Eastern Talent Plan”

   Email: qinqinhu@sjtu.edu.cn

   Office Phone: +86(0)21-63846590*776975

   Research Interest: Basic and application research on Biosensors and Molecular Diagnosis

Dr. Qinqin Hu received her Ph.D. degree in biosystem engineering from Zhejiang University  in 2016 and completed postdoctoral training before serving as an assistant professor at the Institutes of Biomedicine, Fudan University (2016-2021). Currently, she is an associate professor at School of Global Health, Shanghai Jiao Tong University School of Medicine (2022-present). Her expertise lies in developing biosensors and screening functional nucleic acids, especially focusing on 1) novel molecular diagnostic techniques (CRISPR/Cas-based) and nano/optical biosensors for food hazards surveillance and rapid disease diagnosis; 2) In vitro selection of functional nucleic acids including DNAzymes or aptamers for the identification of potential disease-related molecules. Dr. Hu has published over 30 papers (total IF > 200), including 6 papers with impact factors over 10 and more than 1500 citations (ESI = 1). She has also published two academic books and authorized or applied 6 patents. Additionally, she has led 6 research projects including the General Program and Youth Program supported by the National Natural Science Foundation of China.

Publications

1.Qinqin Hu^#, Zongxuan Tong#, Ayimukedisi Yalikong#, Li-Ping Ge#,Qiang Shi, Xinyu Du, Pu Wang, Xi-Yu Liu, Wuqiang Zhan, Xia Gao, Di Sun, Tong Fu, Dan Ye, Jie Liu, Chunhai Fan, Yun-Shi Zhong^*, Yi-Zhou Jiang^*, Hongzhou Gu^*. DNAzyme-Based Faithful Probing-and-Pulldown to Identify Candidate Biomarkers of Low Abundance. Nature Chemistry 2024, 16: 122-131.

2.Huimin Li, Leshan Xiu, Xiaokui Guo, Qinqin Hu^*, Kun Yin^*. Spatiotemporal dual-dimensional separation enables ultra-simple one-pot CRISPR-based molecular diagnostics, Chemical Engineering Journal, 2024, 482: 148872.

3.Fumin Chen, Chenang Lyu, Zhao Li, Leshan Xiu, Huimin Li, Yi Xie, Runzhen Cao, Qinqin Hu^*, Kun Yin^*. Fully Integrated Microfluidic Platform for Multiplexed Detection of Hunov by a Dynamic Confine-Space-Implemented One-Pot Rpa-Lamp System, Advanced Science, 2023, 2306612.

4.Si-Yu Gu, Fu-Min Chen, Chen-Sheng Zhang, Yi-Bin Zhou, Tian-Yun Li, Ne Qiang, Xiao-Xi Zhang, Jing-Shu Liu, Shu-Xun Wang, Xue-Chen Yang, Xiao-Kui Guo, Qin-Qin Hu^*, Xiao-Bei Deng^*, Le-Fei Han*. Assessing food security performance from the One Health concept: an evaluation tool based on the Global One Health Index. Infectious Diseases of Poverty 2023, 12, 88.

5.Yawen He, Qinqin Hu, Samantha San, Tom Kasputis, Maria Gabriella Duarte Splinter, Kun Yin^*, Juhong Chen^*. CRISPR-based biosensors for human health: A novel strategy to detect emerging infectious diseases. TrAC Trends in Analytical Chemistry 2023, 168, 117342.

6.Fumin Chen#, Qinqin Hu^#, Huimin Li, Yi Xie, Leshan Xiu, Yuqian Zhang, Xiaokui Guo^*, Kun Yin^*. Multiplex Detection of Infectious Diseases on Microfluidic Platforms. Biosensors 2023, 13, 410.

7.Huimin Li#, Yi Xie#, Fumin Chen, Huiwen Bai, Leshan Xiu, Xiaonong Zhou, Xiaokui Guo^*, Qinqin Hu^*, Kun Yin^*. Amplification-free CRISPR/Cas Detection Technology: Challenges, Strategies, and Perspectives. Chemical Society Reviews 2023, 52(1):361-382.

8.Qinqin Hu^#; Zheyan Fang#; Junbo Ge^*; Hua Li^*. Nanotechnology for Cardiovascular Diseases. The Innovation 2022, 3(2): 100214.

9.Qinqin Hu^#; Hua Li#; Lihua Wang; Hongzhou Gu^*; Chunhai Fan^*. “DNA Nanotechnology Enabled Drug Delivery systems.” Chemical Reviews. 2019, 119(10): 6459-6506.

10.Qinqin Hu^#; Sheng Wang; Lihua Wang; Hongzhou Gu^*; Chunhai Fan^*. DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides. Advanced Healthcare Materials. 2018, 7, 1-19.

11.Qinqin H^u#; Ronghui Wang; Hong Wang; Michael F. Slavik; Yanbin Li^*. “Selection of Acrylamide-Specific Aptamers by a Quartz Crystal Microbalance Combined SELEX Method and Their Application in Rapid and Specific Detection of Acrylamide.” Sensors and Actuators B: Chemical 2018, 273, 220-227

12.Qinqin Hu^#; Yingchun Fu; Xiahong Xu; Zhaohui Qiao; Ronghui Wang;Ying Zhang; Yanbin Li^*. “A Colorimetric Detection of Acrylamide in Potato Chips Based on Nucleohile-Initiated Thiol-Ene Michael Addition.” Analyst 2016, 141, 1136-1143.

13.Qinqin Hu^#; Xiahong Xu; Yingchun Fu; Yanbin L^i*. “Rapid methods for Detecting Acrylamide in Thermally Processed Foods: A Review.” Food Control 2015, 56, 135-146.

14.Qinqin Hu^#; Xiahong Xu; Zhanming Li; Ying Zhang; Jianping Wang; Yingchun Fu; Yanbin Li^*. “Detection of Acrylamide in Potato Chips Using a Fluorescent Sensing Method Based on Acrylamide Polymerization-Induced Distance Increase Between Quantum Dots.” Biosensors and Bioelectronics 2014, 54, 64-71.

15.Qinqin Hu^#; Xiahong Xu; Zhanming Li; Ying Zhang; Yanbin Li^*. “Rapid Detection of Acrylamide in Food Using a Fluorescent Sensing Method Based on Functional CdSe/ZnS Quantum Dots.” IEEE Sensors 2013, 414-417.

16.Yi Xie, Huimin Li, Fumin Chen, Srisruthi Udayakumar, Khyati Arora, Hui Chen, Yang Lan, Qinqin Hu, Xiaonong Zhou, Xiaokui Guo^*, Leshan Xiu*, and Kun Yin^*. Clustered Regularly Interspaced short palindromic repeats-Based Microfluidic System in Infectious Diseases Diagnosis: Current Status, Challenges, and Perspectives. Advanced Science 2022, 2204172.

17.Zongxuan#, Tong; Qinqin Hu; Hongzhou Gu^*. “Deoxyribozymes: Selection, Biosensing and Outlook.” Chemical Journal of Chinese Universities-Chinese 2020, 41 (11), 2345-2355.

18.Hong Wang#^*; Lijun Wang; Qinqin Hu; Ronghui Wang; Yanbin Li; Michael Kidd. “Rapid and Sensitive Detection of Campylobacter jejuni in Poultry Products Using a Nanoparticle-Based Piezoelectric Immunosensor Integrated with Magnetic Immunoseparation.” Journal of Food Protection 2018, 81 (8), 1321–1330.

19.Zhuo Zhao#; Lizhou Xu; Qinqin Hu; Ronghui Wang; Hong Wang; Yanbin Li^*. “A portable and automatic biosensing instrument for simultaneous detection of foodborne pathogens using nanobead-based magnetic separation and quantum dot-labeled fluorescent measurement.” 2016 ASABE Annual International Meeting 162461406. (doi:10.13031/aim.20162461406)

20.Huiyan Li#; Fangfei Yin; Xinyi Li; Wannan Jia; Jia Ding; Li Zhang; Zhonghua Wang; Qinqin Hu; Jieliang Zuo; Huliang Jia; Li hua Wang; Chunhai Fan^*; Hongzhou Gu*; Jian Wu.^* “Novel aptasensor-based assay of sonic hedgehog ligand for detection of portal vein invasion of hepatocellular carcinoma” Biosensors and Bioelectronics 2021, 174, 112738.