Name: Kokouvi KASSEGNE, PhD, Assistant Professor, Eligible to Supervise Master and PhD (as Co-Supervisor)

E-mail:kassegnek@sjtu.edu.cn

Office Tel: +86-21-63846590*776974

Research Interest: Protozoan Infection and Host Immunity

Professional Network: https://researchgate.net/profile/Kokouvi-Kassegne

Biography

Dr Kokouvi Kassegne is Assistant Professor and Supervisor of Master and PhD (as Co-Supervisor), from the School of Global Health, Shanghai Jiao Tong University School of Medicine. Prof. Kassegne’s team investigates on protozoan parasites infection and host immunity.

His primary research interest and expertise focuses on the use of immunologic, genetic, and high-throughput tools for the control of parasitic diseases, especially malaria. His current research is targeted toPlasmodium-human host interactions—the roles surface proteins play in malaria severity/immunity and understanding of functional variations of malaria blood-stage molecules for the development of severe malaria vaccines and malaria diagnostics as well. He has long-standing experience in the design, implementation, coordination, and evaluation of (i) molecular and serological epidemiology in different settings, (ii) humoral immune responses to antigens for correlates of clinical immunity, (iii) genomic research to understand molecular variations in protozoan parasites, and (iv) in scientific publications (over 20 publications in peer-reviewed international journals, 1 book chapter).

Prof. Kassegne also has a keen interest in tick-borne infections and currently leads a study on transmission risks of tick-borne diseases in Chongming Island of Shanghai, China.

After his PhD at the prestigious Zhejiang University, China, he has been working in renowned research and academic institutions in China. During his career, he has been awarded for Excellent Youth Academic Report and 2 scientific research project prizes. He has also been a member of research groups awarded by the National Natural Science Foundation of China and, has received and accepted more than 10 invitations to speak sessions. He also serves as Editorial Board Member forMolecular Biology & Nanomedicine and peer-reviews manuscript forFrontiers in Cellular and Infection Microbiology, Frontiers in Microbiology, andJournal of Blood Medicine.

Prof. Kassegne scientific advice was requested by the National Institute of Parasitic Diseases, China CDC as: (i) investigator for The United Nations Office for Project Services-funded WHA-WHO demonstration project Development for Easy to Use and Affordable Biomarkers as Diagnostics for Types II and III Diseases, and (ii) instructor and facilitator for the Australia-China-Papua New Guinea Trilateral Pilot Cooperation on Malaria Control Project.

Selected Publications

A) First or Corresponding authorship

Yin Jing-Xian, Agbana Yannick Luther, Sun Zhi-Shan, Fei Si-Wei, Zhao Han-Qing, Zhou Xiao-Nong, Chen Jun-Hu, Kassegne Kokouvi*. Increased interleukin-6 is associated with long COVID-19: a systematic review and meta-analysis. Infectious Diseases of Poverty. 2023,12(1):43.1.(JCR: Q1)

Zhao Han-Qing, Fei Si-Wei, Yin Jing-Xian, Li Qin, Jiang Tian-Ge, Guo Zhao-Yu, Xue Jing-Bo, Han Le-Fei, Zhang Xiao-Xi, Xia Shan, Zhang Yi, Guo Xiao-Kui, Kassegne Kokouvi*.2.Assessment of performance for a key indicator of One Health: evidence based on One Health index for zoonoses in Sub-Saharan Africa. Infectious Diseases of Poverty. 2022,11(1):109. (JCR: Q1)

Kassegne Kokouvi*,  Fei Si-Wei, Ananou Koffigan, et al. A Molecular Investigation of Malaria Infections from High-Transmission Areas of Southern Togo Reveals Different Species of Plasmodium Parasites. Frontiers in Microbiology. 2021,12:732923. (JCR: Q1)

Kassegne Kokouvi, Zhou Xiao-Nong, Chen Jun-Hu. Editorial: Vectors and Vector-Borne Parasitic Diseases: Infection, Immunity, and Evolution. Frontiers in Immunology. 2021,12:729415. (JCR: Q1)

Kassegne Kokouvi*,Komi Koukoura Komi, Shen Hai-Mo, et al. Genome-Wide Analysis of the Malaria Parasite Plasmodium falciparum Isolates From Togo Reveals Selective Signals in Immune Selection-Related Antigen Genes. Frontiers in Immunology. 2020,11:552698.(JCR: Q1)

Kassegne Kokouvi, Abe Eniola Michael, Cui Yan-Bing, et al. Contribution of Plasmodium immunomics: potential impact for serological testing and surveillance of malaria. Expert Review of Proteomics. 2019,16,(2):117-129. (JCR: Q2)

Kassegne Kokouvi,, Zhang Ting, Chen Shen-Bo, et al. Study roadmap for high-throughput development of easy to use and affordable biomarkers as diagnostics for tropical diseases: a focus on malaria and schistosomiasis. Infectious Diseases of Poverty. 2017,6,(1):130. (JCR: Q1)

Kassegne Kokouvi, Abe Eniola Michael, Chen Jun-Hu, et al. Immunomic approaches for antigen discovery of human parasites. Expert Review of Proteomics. 2016,13,(12):1091-1101. (JCR: Q2)

Kassegne Kokouvi, Hu Weilin, Ojcius David M, et al. Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic Leptospira species. Journal of Infectious Diseases. 2014,209,(7):1105-1115. (JCR: Q1)

Zhao JinFang, Tan Panli, Wang Zhejiong, Hu Weilin, Yan Jie, Kassegne Kokouvi*.10. Collagenase activity and pathogenic mechanism of colA gene product of Leptospira interrogans. Chinese Journal of Zoonoses. 2016; 31 (1). (In Chinese)

B) Co-authorship

Ge Jieyun, Wang Qiubo, Chen Gangcheng, Kassegne Kokouvi, et al. Immunogenicity and antigenicity of a conserved fragment of the rhoptry-associated membrane antigen of Plasmodium vivax. Parasites & Vectors. 2022,15,(1):428. (JCR: Q1)

Zhang Xiao-Xi, Liu Jing-Shu, Han Le-Fei, Li Shi-Zhu, Li Odel Y,Kassegne Kokouvi,et al. Towards a global One Health index: a potential assessment tool for One Health performance. Infectious Diseases of Poverty. 2022,11,(1):57.(JCR: Q1)

Wang Duoquan, Lv Shan, Ding Wei, Lu Shenning, Zhang Hongwei, Kassegne Kokouvi,, et al. Could China's journey of malaria elimination extend to Africa? Infectious Diseases of Poverty. 2022,11,(1):55. (JCR: Q1)

Cui Yan-Bing, Shen Hai-Mo, Chen Shen-Bo,Kassegne Kokouvi, et al. Genetic Diversity and Selection of Plasmodium vivax Apical Membrane Antigen-1 in China-Myanmar Border of Yunnan Province, China, 2009-2016. Frontiers in Cellular and Infection Microbiology. 2022,11:742189.(JCR: Q2)

Fu Haitian, Lu Jiachen, Zhang Xinxin, Wang Bo, Sun Yifan, Lei Yao, Shen Feihu,Kassegne Kokouvi,et al. Identification of the Recombinant Plasmodium vivax Surface-Related Antigen as a Possible Immune Evasion Factor Against Human Splenic Fibroblasts by Targeting ITGB1. Frontiers in Cellular and Infection Microbiology. 2021,9:764109.(JCR: Q2)

Shi Tian-Qi, Shen Hai-Mo, Chen Shen-Bo, Kassegne Kokouvi,et al. Genetic Diversity and Natural Selection of Plasmodium vivax Duffy Binding Protein-II From China-Myanmar Border of Yunnan Province, China. Frontiers in Microbiology. 2021,12:758061.(JCR: Q1)

Xu Qiwen, Liu Sihong, Kassegne Kokouvi, et al. Genetic diversity and immunogenicity of the merozoite surface protein 1 C-terminal 19-kDa fragment of Plasmodium ovale imported from Africa into China. Parasites & Vectors. 2021,14(1):583. (JCR: Q1)

Shi Shan-Mei, Shi Tian-Qi, Chen Shen-Bo, Cui Yan-Bing,Kassegne Kokouvi, et al. Genome-Wide Scans for Ghanaian Plasmodium falciparum Genes Under Selection from Local and Chinese Host Populations. Frontiers in Cellular and Infection Microbiology. 2021,11:630797.(JCR: Q2)

Shen Fei-Hu, Ong Jessica Jie Ying, Sun Yi-Fan, Lei Yao, Chu Rui-Lin, Kassegne Kokouvi, et al. A Chimeric Plasmodium vivax Merozoite Surface Protein Antibody Recognizes and Blocks Erythrocytic P. cynomolgi Berok Merozoites In Vitro. Infection and Immunity. 2021,89,(2):e00645-20.(JCR: Q3)

Uwase Juliette, Chu Ruilin,Kassegne Kokouvi, et al. Immunogenicity analysis of conserved fragments in Plasmodium ovale species merozoite surface protein 4. Malaria Journal. 2020,19,(1):126. (JCR: Q3)

Agbana Yannick Luther, Ni Yueli, Zhou Meiling, Zhang Qiao,Kassegne Kokouvi, et al. Garlic-derived bioactive compound S-allylcysteine inhibits cancer progression through diverse molecular mechanisms. Nutrition research. 2020,73, 1–14. (JCR: Q3)

Shen Hai-Mo, Chen Shen-Bo, Cui Yan-Bing, Xu Bin, Kassegne Kokouvi,et al. Whole-genome sequencing and analysis of Plasmodium falciparum isolates from China-Myanmar border area. Infectious Diseases of Poverty. 2018,7,(1):118. (JCR: Q1)

Abe Eniola Michael, Guan Wei, Guo Yun-Hai, Kassegne Kokouvi,et al. Differentiating snail intermediate hosts of Schistosoma spp. using molecular approaches: fundamental to successful integrated control mechanism in Africa. Infectious Diseases of Poverty. 2018,7,(1):29. (JCR: Q1)

Chen Shen-Bo, Wang Yue, Kassegne Kokouvi,14.et al. Whole-genome sequencing of a Plasmodium vivax clinical isolate exhibits geographical characteristics and high genetic variation in China-Myanmar border area. BMC Genomics. 2017,18,(1):131.  (JCR: Q2)

Team’s Member

Si-Wei Fei, Master, siweifei@sjtu.edu.cn

Han-Qing Zhao, PhD, zhaohanqing98@sjtu.edu.cn

Jing-Xian Yin, Master, chyjx0718@sjtu.edu.cn