Name: Leshan XIU, Assistant Professor

　Degree: MD

　Email Address: xiuls@sjtu.edu.cn

　Office Address: Rm 412, Building 1, 280 South Chongqing Road, Shanghai

　Office Tel: 021-63846590

　Research Interest: Molecular methods for pathogen identification and AMR detection; Combating infectious diseases and

　antimicrobial resistance using One Health approach; Development of novel tools for disease diagnostics based on optical

　biosensors

Leshan Xiu is an assistant professor in the School of Global Health, Shanghai Jiao Tong University School of Medicine. He received an MD degree from Peking Union Medical College, Tsinghua University in 2021. Dr. Xiu's research overall aim is to improve diagnostics, clinical and public health strategies to aid in the control of infectious diseases and antimicrobial resistance. Currently, his research program bridges infectious diseases and clinical microbiology, with projects focused on the development and evaluation of novel diagnostic tests for infectious diseases and antimicrobial resistance. He has published over 25 research articles, including Clinical infectious diseases, One Health, Journal of Molecular Diagnostics, Journal of Antimicrobial Chemotherapy, and Microbial Biotechnology.

Education：

2011.09 – 2015.06, North China University of Science and Technology, Bachelor

2015.09 – 2018.06, Peking Union Medical College, Tsinghua University, Master

2018.09 – 2021.06, Peking Union Medical College, Tsinghua University, MD

2019.09 – 2020.09, Duke University, Joint PhD student

Appointments：

2021.07-present, Shanghai Jiao Tong University School of Medicine, Assistant Professor

Academic Participation and Activities：

Guest Editor for Frontiers in Cellular and Infection Microbiology

Research Interest：

Molecular methods for pathogen identification and AMR detection; Combating infectious diseases and antimicrobial resistance using One Health approach; Development of novel tools for disease diagnostics based on optical biosensors

Publications：

1　Xiu L^*, Li H, Hu Q, Zhang Y, Chen S, Wang C, Zhou X, Chen J^*, Kun Yin^*. A Versatile Microfluidic Platform for Malaria Infection Screening and Plasmodium Species Genotyping. Ebiomedicine. 2023,

2　Xiu L, Wang L, Li Y, Hu L, Huang J, Yong G, Wang Y, Cao W, Dong Y, Gu W^*, Peng J^*. Multicentre Clinical Evaluation of a Molecular Diagnostic Assay to Identify Neisseria gonorrhoeae Infection and Detect Antimicrobial Resistance. Int J Antimicrob Agents. 2023, 61(5):106785

3　Xiu L, Li Y, Wang F, Zhang C, Li Y, Zeng Y, Yin Y, Peng J. Multiplex High-Resolution Melting Assay for Simultaneous Identification of Molecular Markers Associated with Extended-Spectrum Cephalosporins and Azithromycin Resistance in Neisseria gonorrhoeae. J Mol Diagn. 2020, 22(11):1344-1355

4　Xiu L, Li Y, Zhang C, Li Y, Zeng Y, Wang F, Peng J. A molecular screening assay to identify Chlamydia trachomatis and distinguish new variants of C. trachomatis from wild-type. Microb Biotechnol, 2021, 14:668-676

5　Xiu L, Binder RA, Alarja NA, Kochek K, Coleman KK, Than ST, Bailey ES, Bui VN, Toh T, Erdman DD, Grey GC. A RT-PCR assay for the detection of coronaviruses from four genera. J Clin Virol. 2020,128:104391

6　Xiu L, Yuan Q, Li Y, Zhang C, Tang L, Peng J. Emergence of ceftriaxone-resistant Neisseria gonorrhoeae strains harbouring a novel mosaic penA gene in China. J Antimicrob Chemother. 2020, 75(4):907-910

7　Xiu L, Zhang C, Li Y, Wang F, Peng J. High-resolution melting analysis for rapid detection of the internationally spreading ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone. J Antimicrob Chemother. 2020, 75(1):106-109

8　Xiu L, Zhang C, Li Y, Wang F, Peng J. Simultaneous detection of eleven sexually transmitted agents using multiplexed PCR coupled with MALDI-TOF analysis. Infect Drug Resist. 2019, 12:2671-2682

9　Xiu L, Zhang C, Wu Z, Peng J. Establishment and Application of a Universal Coronavirus Screening Method using MALDI-TOF mass spectrometry. Front Microbiol. 2017, 8:1510

10　Xie Y^#, Li H^#, Chen F, Udayakumar S, Arora K, Chen H, Lan Y, Hu Q, Zhou X, Guo X^*, Xiu L^*, Yin K^*. Clustered Regularly Interspaced short palindromic repeats-Based Microfluidic System in Infectious Diseases Diagnosis: Current Status, Challenges, and Perspectives. Adv Sci (Weinh). 2022, 9(34):e2204172 

11　Li Y^#, Xiu L^#, Wang L, Zhang L, Wang F, Peng J^*. Rapid Detection of Antimicrobial Resistance in Mycoplasma genitalium by High-Resolution Melting Analysis with Unlabeled Probes. Microbiol Spectr. 2022, 10(4):e0101422 

12　Sun L^#, Xiu L^#, Zhang C^#, Xiao Y, Li Y, Zhang L, Ren L^*, Peng J^*. Detection and classification of SARS-CoV-2 using high-resolution melting analysis. Microb Biotechnol, 2022, 15(6):1883-1894 

13　Li Y#, Zhang L#, Xiu L^#, Wang D, Zeng Y, Wang F, Yin Y, Peng J^*. A Multiplex Molecular Assay for Detection of Six penA Codons To Predict Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2022, 66(3):e0170921 

14　Zhang C^#, Song F^#, Xiu L^#, Liu Y, Yang J, Yao L, Peng J. Identification and characterization of a novel rodent bocavirus from different rodent species in China. Emerg Microbes Infect. 2018, 7(1):48 

15　Zhang C^#, Xiu L^#, Xiao Y, Xie Z, Ren L, Peng J. Simultaneous Detection of Key Bacterial Pathogens Related to Pneumonia and Meningitis Using Multiplex PCR Coupled With Mass Spectrometry. Front Cell Infect Microbiol. 2018, 8:107 

16　Li Y, Xiu L, Liu J, Zhang C, Wang F, Yin Y, Peng J. A multiplex assay for characterization of antimicrobial resistance in Neisseria gonorrhoeae using multi-PCR coupled with mass spectrometry. J Antimicrob Chemother. 2020, 75(10):2817-25

17　Binder RA, Alarja NA, Robie ER, Kochek KE, Xiu L, Rocha-Melogno L, Abdelgadir A, Goli SV, Farrell AS, Coleman KK, Turner AL, Lee MJ, Polage CR, Anderson BD, Gray GC. Environmental and Aerosolized SARS-CoV-2 Among Hospitalized COVID-19 Patients. J Infect Dis. 2020, 222(11):1798-1806

18　Zhang C, Wang F, Zhu C, Xiu L, Li Y, Li L, Liu B, Li Y, Zeng Y, Guo B, Peng J. Determining antimicrobial resistance profiles and identifying novel mutations of Neisseria gonorrhoeae genomes obtained by multiplexed MinION sequencing. Sci China Life Sci. 2020, 63:1063-70

19　Yuan Q, Li Y, Xiu L, Zhang C, Fu Y, Jiang C, Tang L, Peng J. Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017-2018. Emerg Microbes Infect. 2019, 8:1546-9

20　Zhang C, Hu T, Xiu L, Li Y, Peng J. Use of Ultra-Deep Sequencing in a Patient with Tuberculous Coxitis Shows Its Limitations in Extrapulmonary Tuberculosis Diagnostics: A Case Report. Infect Drug Resist. 2019, 12:3739-43

21　Peng J, Yin Y, Chen S, Yang J, Dai X, Zheng H, Gu W, Zhu B, Yong G, Zhong N, Hu L, Cao W, Zheng Z, Wang F, Zhi Q, Zhang C, Xiu L, Liu B, Dong J, Sun L, Zhu Y, Chen X, Jin Q. A Whole-genome Sequencing Analysis of Neisseria gonorrhoeae Isolates in China: An Observational Study. EClinicalMedicine, 2019,7:47-54)

22　Zhang C, Xiu L, Li Y, Sun L, Ren L, Li Y, Zeng Y, Wang F, Peng J. Multiplex PCR and Nanopore Sequencing of Genes Associated with Antimicrobial Resistance in Neisseria gonorrhoeae Directly from Clinical Samples. Clin Chem. 2021, 67(4):610-620

23　Li Y, Li Y, Xiu L, Zeng Y, Zhang C, Sun L, Zhang L, Wang F, Peng J. Typing of Neisseria Gonorrhoeae isolates in Shenzhen, China from 2014-2018 reveals the shift of genotypes associated with antimicrobial resistance. Antimicrob Agents Chemother. 2021, 65(5):e02311-20

24　Li H, Xie Y, Chen F, Bai H, Xiu L, Zhou X, Guo X, Hu Q, Yin K. Amplification-free CRISPR/Cas detection technology: challenges, strategies, and perspectives. Chem Soc Rev. 2023, 52(1):361-382

25　Sun L, Zhang C, An S, Chen X, Li Y, Xiu L, Xu B, Xie Z, Peng J. Comprehensive Description of Pathogens and Antibiotic Treatment Guidance in Children with Community-acquired Pneumonia Using Combined Mass Spectrometry Methods. Front Cell Infect Microbiol. 2021, 11:695134

26　Vlasova AN, Diaz A, Damtie D, Xiu L, Toh TH, Lee JS, Saif LJ, Gray GC. Novel Canine Coronavirus Isolated from a Hospitalized Pneumonia Patient, East Malaysia. Clin Infect Disl. 2022, 74(3):446-454

27　Wang X, Xiu L, Binder RA, Toh TH, Lee JS, Ting J, Than ST, Qi W, Coleman KK, Perera D, Ma M, Gray GC. A pan-coronavirus RT-PCR assay for rapid viral screening of animal, human, and environmental specimens. One Health. 2021, 13:100274

28　Chen F, Hu Q, Li H, Xie Y, Xiu L, Zhang Y, Guo X, Yin K. Multiplex Detection of Infectious Diseases on Microfluidic Platforms.Biosensors (Basel). 2023, 13(3):410

29　Liu T, Xiu L, Yin K, Li S. Detection and classification of SARS-CoV-2 using high-resolution melting analysis. Clin Transl Discov. 2022, 2(1):e23