Name：Zhao-Jun Wang Professor

Email：zjwang@sjtu.edu.cn

Office Tel：021-63846590-776349

Research interest: Infection and Immunity

Professor in the Department of Microbiology and Immunology in Shanghai Jiao Tong University School of Medicine. Principle Investigator in Shanghai Institute of Immunology. Awarded with Zhiyuan Honors Teaching Faculty of Shanghai Jiao Tong University.

Served as the vice dean of School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine.

Research Interests

Innate host immunity is the first line of defense against pathogen infection, playing a critical role in host resistance to pathogenic microorganisms. Prof Wang’s lab focuses on how leukocytes adapt to infectious or inflammatory environments and regulate their functions in response to diverse pathogens, such as protozoa and helminths.

Selected Publications

1.Li Q., Yue T., Du X., Tang Z., Cui J., Wang W., Xia W., Ren B., Kan S., Li C., Wu C., Niu X., Li B., Lin K., Luo J., Chen G., Wang Z. Hsc70 mediated autophagic degradation of oxidized prl2 is responsible for osteoclastogenesis and inflammatory bone destruction. Cell Death Differ. 2023;30(3):647-659.

2.Kan S., Li Q., Li H. M., Yao Y. H., Du X. Y., Wu C. Y., Chen G. J., Guo X. K., Qian M. B., Wang Z. J. Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex. PLoS Negl Trop Dis. 2022;16(9):e0010726.

3.Wu C., Du X., Tang L., Wu J., Zhao W., Guo X., Liu D., Hu W., Helmby H., Chen G., Wang Z. Schistosoma japonicum sje16.7 protein promotes tumor development via the receptor for advanced glycation end products (rage). Front Immunol. 2020;11:1767.

4.Du X., Zhang Y., Li X., Li Q., Wu C., Chen G., Guo X., Weng Y., Wang Z. Prl2 serves as a negative regulator in cell adaptation to oxidative stress. Cell Biosci. 2019;9(1):96.

5.Yin C., Wu C., Du X., Fang Y., Pu J., Wu J., Tang L., Zhao W., Weng Y., Guo X., Chen G., Wang Z. Prl2 controls phagocyte bactericidal activity by sensing and regulating ros. Front Immunol. 2018;9:2609.

6.Fayngerts S. A.*, Wang Z.*, Zamani A., Sun H., Boggs A. E., Porturas T. P., Xie W., Lin M., Cathopoulis T., Goldsmith J. R., Vourekas A., Chen Y. H. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein tipe2. Nat Immunol. 2017;18(12):1353-1360.

7.Fang Y., Wu C., Chen Q., Wu J., Yang Y., Guo X., Chen G., Wang Z. Sje16.7 activates macrophages and promotes schistosoma japonicum egg-induced granuloma development. Acta Trop. 2015;149:49-58.

8.Wu C., Chen Q., Fang Y., Wu J., Han Y., Wang Y., Yang Y., Chu M., Feng Y., Tan L., Guo X., Hu W., Wang Z. Schistosoma japonicum egg specific protein sje16.7 recruits neutrophils and induces inflammatory hepatic granuloma initiation. PLoS Negl Trop Dis. 2014;8(2):e2703.

9.Wang Z., Fayngerts S., Wang P., Sun H., Johnson D. S., Ruan Q., Guo W., Chen Y. H. Tipe2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection. Proc Natl Acad Sci U S A. 2012;109(38):15413-15418.

10.Wu C. Y., Feng Y., Qian G. C., Wu J. H., Luo J., Wang Y., Chen G. J., Guo X. K., Wang Z. J. Alpha-galactosylceramide protects mice from lethal coxsackievirus b3 infection and subsequent myocarditis. Clin Exp Immunol. 2010;162(1):178-187.

11.Wang Z., Qiu J., Guo T. B., Liu A., Wang Y., Li Y., Zhang J. Z. Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis. J Immunol. 2007;179(9):5958-5965.

12.Wang Z., Hong J., Sun W., Xu G., Li N., Chen X., Liu A., Xu L., Sun B., Zhang J. Z. Role of ifn-gamma in induction of foxp3 and conversion of cd4+ cd25- t cells to cd4+ tregs. J Clin Invest. 2006;116(9):2434-2441.