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​王蒙 青年副研究员

日期:2023-11-20 点击数: 来源:

邮箱:wm19921276529@163.com

研究方向:1. 厌食症的中枢调控机制;2. 肥胖基因MC4R引起中枢炎症和代谢紊乱的分子机制

 

教育经历:

2016.09-2021.06 同济大学生命科学与技术学院 生物学 博士

2012.09-2016.06 广西大学生命科学与技术学院 生物工程 学士

 

工作经历:

2023.10-至今 欧洲杯竞猜平台松江研究院 青年副研究员

2021.09-2023.10 欧洲杯竞猜平台 基础医学 博士后

代表性论文:

1. Meng Wang*; Jianjun Lyu; Chao Zhang. Single transmembrane GPCR modulating proteins: neither single nor simple, Protein & Cell, 2023; pwad035. doi:10.1093/procel/pwad035.

2. Meng Wang*; Xiaozhu Wang*; Bopei Jiang; Yue Zhai; Jihong Zheng; Liu Yang; Xiaolu Tai; Yunpeng Li; Shaliu Fu; Jing Xu; Xiaowei Lei; Zhe Kuang; Cong Zhang; Xuanxuan Bai; Mingyu Li; Tao Zan; Shen Qu; Qingfeng Li; Chao Zhang. Identification of MRAP protein family as broadspectrum GPCR Modulators,

Clinical and Translational Medicine, 2022.

3. Meng Wang*; Jing Xu*; Xiaowei Lei*; Cong Zhang; Shang-Yun Liu; Li-Na Jin; Chao Zhang. Selective Interactions of Mouse Melanocortin Receptor Accessory Proteins with Somatostatin Receptors, Cells, 2022, 11(2): 267.

4. Meng Wang*; Yue Zhai; Liumei Lu; Cong Zhang; Na Li; Song Xue; Daofu Cheng; Shaliu Fu; Qi Liu; Chao Zhang. Elucidation of the dimeric interplay of dual MRAP2 proteins in the zebrafish, Journal of Cellular Physiology, 2021, 236(9): 6472-6480.

5. Meng Wang*; Linyu Pi*; Xiaowei Lei*; Lei Li; Jing Xu; Zhe Kuang; Cong Zhang; Liang Li; Chao Zhang. Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer, Frontiers in Endocrinology, 2021, 12: 750797.

6. Meng Wang*; Yue Zhai; Xiaowei Lei; Jing Xu; Bopei Jiang; Zhe Kuang; Cong Zhang; Shangyun Liu; Shan Bian; Xiao-Mei Yang; Tao Zan; Li-Na Jin; Qingfeng Li; Chao Zhang. Determination of the interaction and pharmacological modulation of MCHR1 signaling by C terminus of MRAP2 protein, Frontiers in Endocrinology, 2022, 13: 848728.

7. Meng Wang*; Yijun Chen; Ming Zhu; Bingxin Xu; Wenxuan Guo; Yunsong Lyu; Chao Zhang. Pharmacological modulation of melanocortin-4 receptor by melanocortin receptor accessory protein 2 in Nile tilapia. General and Comparative Endocrinology, 2019 Oct 1; 282:113219.

8. Jing Xu*; Meng Wang*; Yanbin Fu; Cong Zhang; Zhe Kuang; Shan Bian; Rui Wan; Shen Qu; Chao Zhang. Reversion of MRAP2 Protein Sequence Generates a Functional Novel Pharmacological Modulator for MC4R Signaling, biology, 2022, 11(6), 874.

9. Ming Zhu*; Meng Wang*; Yijun Chen; Chao Zhang. Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish, Journal of Molecular Endocrinology, 2018, 62(1):27-36.

10. Xiaozhu Wang*; Song Xue; Xiaowei Lei; Wenqi Song; Lei Li; Xuan Li; Yanbin Fu; Cong Zhang; Hailin Zhang; Yao Luo; Meng Wang(共通讯); Gufa Lin; Chao Zhang; Jing Guo. Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling, Frontiers in

Endocrinology, 2022 Feb 17; 13: 820896.

 

荣誉和奖励:

2022年 上海市“超级博士后”激励计划

2022年 中国康复医学会科学技术奖一等奖(肢体移植后创面愈合及功能重建

的分子通路研究和相关康复技术的应用)

2016.09-2021.06 光华奖学金,同济大学校优秀学生等

2012.09-2016.06 国家奖学金,校长奖学金,自治区优秀毕业生,自治区优秀学生干部等

 

近五年主持或参加的国家自然科学基金项目/课题:

1. 72批博士后面上项目二等资助,单细胞测序揭示肥胖基因LeptinMC4R介导中枢性神经炎性的不同分子机制,2022M722127, 2022.11-2023.118万元结题,主持。

2. 国家自然基金面上项目,81570760MRAP2作为黑色素皮质激素第四受体MC4R辅助蛋白的进化及调控机制研究,2016.01-2019.1258万元,结题,参与。

3. 国家自然基金面上项目,31771283,利用斑马鱼模型研究MC4R神经元的单细胞转录组及药理调控机制,2018.01-2021.1260万元,结题,参与。