陈欣 研究员
邮箱: xinchen@shsmu.edu.cn
电话:021-67722498
研究方向: 脑肿瘤的机械特性与机械敏感性离子通道的功能
教育经历
2011-2015 年 中国科学院大学神经生物学,博士
2009-2011 年 中国科学院大学神经生物学,硕士
2005-2009 年 武汉大学生物学,学士
工作经历
2023年-至 今 欧洲杯竞猜平台松江研究院,研究员
2015-2022 年 加拿大多伦多大学病童医院干细胞生物发育及脑肿瘤研究所,博士后
获得荣誉
2022年,上海领军人才(海外)青年人才
2019年,Restracomp Fellowship, The Hospital for Sick Children
2019年,Dr. Choong-Chin Liew Best Paper Award Honorable Mention, Society of Chinese Bioscientists in America
2022年,Award Winning Abstract for the Cancer Neuroscience Meeting, MD AndersonCancer Center
2022年,Garron Family Cancer Centre Travel Award, Garron Family Cancer Centre
课题组关注脑肿瘤及其微环境细胞的机械特性,并探究其中机械信号、电信号和生化信号的相互关联;同时专注于以机械敏感性离子通道为精准诊疗靶点,以期改善脑肿瘤异常的机械特性,达到缓解和治疗病症的目的。主要研究方向为:
1. 解析脑肿瘤干细胞的生物力学特性对其静息态和激活态转换的影响,以及对细胞生化特征的调控,并阐明机械敏感性离子通道在其中的作用。
2. 研究机械敏感性离子通道对脑肿瘤微环境中神经细胞与胶质细胞机械特性的调节以及对其电活动和生化通路的影响,阐明它们在脑肿瘤发生和发展过程中的功能与机制。
3. 探索机械敏感性离子通道对神经免疫系统机械特性的调节,关注相关生物力学过程对神经肿瘤形成和发展的影响和机制。
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Xin Chen#, Ali Momin#, Siyi Wanggou#, Xian Wang, Hyun-Kee Min, Wenkun Dou, Jade Chan, Weifan Dong, Jerry J. Fan, Yi Xiong, Kamilia Talipova, Hongyu Zhao, Yuki X. Chen, Kelly Veerasammy, Adam Fekete, Sachin A. Kumar, Hongwei Liu, Qi Yang,Joe Eun Son, Zhengchao Dou, Malini Hu, Parnian Pardis, Kyle Juraschka, Laura Donovan, Jiao Zhang, Vijay Ramaswamy, Hayden Selvadurai, Peter B. Dirks, Michael D. Taylor, Lu-Yang Wang, Chi-chung Hui, Rinat Abzalimov, Ye He, Yu Sun, Xuejun Li*, and Xi Huang*. Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity. Neuron, 2023, 111: 1-19. (Cover Article)
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Xin Chen, Siyi Wanggou, Ankur Bodalia, Min Zhu, Weifan Dong, Jerry J. Fan, Wen Chi Yin, Hyun-Kee Min, Malini Hu, Diana Draghici, Wenkun Dou, Feng Li, Fiona J. Coutinho, Heather Whetstone, Michelle M. Kushida, Peter B. Dirks, Yuanquan Song, Chi-chung Hui, Yu Sun, Lu-Yang Wang, Xuejun Li, and Xi Huang. A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression. Neuron, 2018, 100(4):799-815 (Best of Neuron 2018 and 2019)
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Xin Chen, Mei-Yu Ruan, and Shi-Qing Cai. KChIP-like Auxiliary Subunits of Kv4 Channels Regulate Excitability of Muscle Cells and Control Male Turning Behavior during Mating in Caenorhabditis elegans. Journal of Neuroscience, 2015, 35:1880 –1891.
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Ali Momin#*, Shahrzad Bahrampour#, Hyun-Kee Min#, Xin Chen#, Xian Wang, Yu Sun, and Xi Huang*. Channeling force in the brain: mechanosensitive ion channels choreograph mechanics and malignancies. Trends in Pharmacological Sciences, 2021, 42(5):367-384 (Invited Review, Cover Article)
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Yi Xiong#, Yihao Zhang#, Na Liu, Yueshuo Li, Hongwei Liu, Qi Yang, Yu Chen, Zhizhi Xia, Xin Chen*, Siyi Wanggou* and Xuejun Li*. Integration of single-cell regulon atlas and multi-omics data for prognostic stratification and personalized treatment prediction in human lung adenocarcinoma. Journal of Translational Medicine, 2023, 25;21(1):499.
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Biren M Dave, Xin Chen, Fraser McCready, Connor S Charton, Rachel M Morley, Jignesh K Tailor, James Ellis, Xi Huang, and Peter B Dirks. Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis. Development, 2023, 150(13): dev201534.
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Wentian Tang, Xin Chen, Xian Wang, Min Zhu, Guanqiao Shan, Tiancong Wang, Wenkun Dou, Jintian Wang, Juhui Law, Zheyuan Gong, Sevan Hopyan*, Xi Huang*, and Yu Sun*. Indentation Induces Instantaneous Nuclear Stiffening and Unfolding of Nuclear Envelop Wrinkles. Proceedings of the National Academy of Sciences, 2023,120(36):e2307356120.
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Xian Wang#, Tiancong Wang#, Xin Chen, Junhui Law, Guanqiao Shan, Wentian Tang, Zheyuan Gong, Peng Pan, Xinyu Liu, Jiangfan Yu, Changhai Ru*, Xi Huang*, and Yu Sun*. Microrobotic Swarms for Intracellular Measurement with Enhanced Signal-to-Noise Ratio. ACS nano, 2022, 16(7): 10824-10839.
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Wenkun Dou, Abdelkader Daoud, Xin Chen, Tiancong Wang, Manpreet Malhi, Zheyuan Gong, Fatemeh Mirshafiei, Min Zhu, Guanqiao Shan, Xi Huang, Jason T. Maynes*, and Yu Sun*. Ultrathin and flexible bioelectronic arrays for functional measurement of iPSC-cardiomyocytes under cardiotropic drug administration and controlled microenvironments. Nano Letters, 2023, 23(6): 2321-2331.
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Michael Pryszlak#, Mallory Wiggans#, Xin Chen, Shyam Patel, Julia Jaramillo, Sarah Burns, Laura Richards, Trevor Pugh, David Kaplan, Xi Huang, Peter Dirks, and Bret J. Pearson. The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. Cell Reports, 2021, 34(13):1-16
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Zhuoran Zhang, Changsheng Dai, Guanqiao Shan, Xin Chen, Hang Liu, Khaled Abdalla, Iryna Kuznyetsova, Sergey Moskovstev, Xi Huang, Clifford Librach, Keith Jarvi and Yu Sun. Quantitative selection of single human sperm with high DNA integrity for intracytoplasmic sperm injection.. Fertility and Sterility, 2021, 116(5):1308-1318
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Xian Wang, Zheyuan Gong, Tiancong Wang, Junhui Law, Xin Chen, Siyi Wanggou, Jintian Wang, Binbin Ying, Michelle Francisco, Weifan Dong, Yi Xiong, Jerry J. Fan, Graham MacLeod, Stephane Angers, Xuejun Li, Peter B. Dirks, Xinyu Liu, Xi Huang*, Yu Sun*. Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes. Science Advances, 2023, 9(13): eade5321
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Michelle A. Francisco, Siyi Wanggou, Jerry J. Fan, Weifan Dong, Xin Chen, Ali Momin, Namal Abeysundara, Hyun-Kee Min, Jade Chan, Rochelle McAdam, Marian Sia, Ronwell J. Pusong, Shixuan Liu, Nish Patel, Vijay Ramaswamy, Xiaochong Wu, Noriyuki Kijima, Lu-Yang Wang, Yuanquan Song, Ran Kafri, Michael D. Taylor, Xuejun Li*, and Xi Huang*. Chloride intracellular channel 1 cooperates with potassium channel to promote medulloblastoma growth. Journal of Experimental Medicine, 2020, 217(5):1-19
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Qiang Jiang#, Kai Li#, Wen-Jing Lu, Shuang Li, Xin Chen, Xi-Juan Liu, Jie Yuan, Qiurong Ding, Feng Lan*, and Shi-Qing Cai*. Identification of small-molecule ion channel modulators in C.elegans channelopathy models. Nature Communications, 2018, 9(1):1-12
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Siyi Wanggou#*, Hongyu Zhao#, Xian Wang, Weifan Dong, Xin Chen, Chaoqian Wang, Hyun-Kee Min, Xiaodi Chen, Hongwei Liu,Yongwei Zhu, Nian Jiang, Xuelei Lin, Peter B. Dirks, Yu Sun, Xuejun Li^, Xi Huang^*. Mechanical heterogeneity dictates alternative splicing and chemoresistance of glioma. Nature Communications, 2023, accepted.
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Weifan Dong, Adam Fekete, Xiaodi Chen, Hongwei Liu, Greg Beilhartz, Xin Chen, Shahrzad Bahrampour, Yi Xiong, Qi Yang, Hongyu Zhao, Tian Kong, Malia Morioka, Geena Jung, Ji-Eun Kim, Daniel Schramek, Peter B. Dirks, Yuanquan Song, Tae-Hee Kim, Ye He,Siyi Wanggou, Xuejun Li, Roman Melnyk, Lu-Yang Wang, Xi Huang. A designer peptide to treat glioblastoma by targeting EAG2-Kvβ2 potassium channel complex-mediated cancer-neuron interaction. Nature Cancer, 2023, accepted.
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Jerry J Fan#, Xin Wang#, Anders W Erickson#, Patryk Skowron#, Xian Wang, Xin Chen, Guanqiao Shan, Shahrzad Bahrampour, Yi Xiong, Weifan Dong, Namal Abeysundara, Michelle A Francisco, Ronwell J Pusong, Raul A Suarez, Hamza Farooq, Borja L Holgado, Xiaochong Wu, Craig Daniels, Adam J Dupuy, Juan Cadinanos, Allan Bradley, Anindya Bagchi, Branden S Moriarity, David A Largaespada, A Sorana Morrissy, Vijay Ramaswamy, Stephen C Mack, Livia Garzia, Peter B Dirks, Siyi Wanggou, Xuejun Li, Yu Sun, Michael D Taylor*, Xi Huang*. In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma. bioRxiv (https://doi.org/10.1101/2022.07.23.501234)
地址: 上海市松江区中山中路746号18号楼305室
邮编:201699
电话/传真:021-67722498
邮箱:xinchen@shsmu.edu.cn