Team
Location:
Hui Dong, Ph.D., Investigator
Email: huidong@shsmu.edu.cn
We study sleep
Education and work experience
2023- Investigator, Songjiang Research Institute,
2022-2023 Associate Investigator, Peking University (with Yulong Li)
2020-2022 Postdoc, Peking University (advisor: Yulong Li)
2016-2020 Postdoc, Fudan University (advisor: Zhili Huang)
2011-2016 Ph.D., Fudan University (advisor: Zhili Huang)
2007-2011 B.S., Lanzhou University
Hui Dong
We all need sleep, but why do we need sleep? This is an important and fundamental biological question. Dr. Dong focuses on the research of the mechanism of sleep-wake regulation, mainly dissecting the neural circuits that control of sleep and wakefulness and monitoring the of neuromodulator dynamic during sleep-wake cycles. By utilizing optogenetics, chemogenetics, viral tracing, and in vivo neuronal activity recording techniques, he has deciphered the neural circuits that regulate sleep and wakefulness in the striatum (Current Biology, 2022; eLife, 2017) and in the dorsal part of the deep mesencephalic nucleus (Cell Discovery, 2022). Furthermore, leveraging novel genetically encoded neurotransmitter/neuromodulator sensors (GENIs), he has elucidated the dynamic release pattern of histamine during sleep-wake cycles (Neuron, 2023). Dr. Dong is using GENIs to study dynamic changes of neuromodulators，including monoamines, neuropeptides and lipids, during sleep-wake cycles, focusing on those with unique sleep-related dynamic patterns to uncover their biological significance.
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Feng, J., Dong, H., Lischinsky, J. E., Zhou, J., Deng, F., Zhuang, C., Miao, X., Wang, H., Li, G., Cai, R., Xie, H., Cui, G., Lin, D. and Li, Y. (2024). Monitoring norepinephrine release in vivo using next-generation GRABNE sensors. Neuron. 112(12):1930-1942
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Deng, F., Wan, J., Li, G., Dong, H., Xia, X., Wang, Y., Li, X., Zhuang, C., Zheng, Y., Liu, L., Yan, Y., Feng, J., Zhao, Y., Xie, H. and Li, Y. (2024). Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo. Nature Methods 21(4): 692-702.
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Zhuo, Y., Luo, B., Yi, X., Dong, H., Miao, X., Wan, J., Williams, J. T., Campbell, M. G., Cai, R., Qian, T., Li, F., Weber, S. J., Wang, L., Li, B., Wei, Y., Li, G., Wang, H., Zheng, Y., Zhao, Y., Wolf, M. E., Zhu, Y., Watabe-Uchida, M. and Li, Y. (2024). Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo. Nature Methods 21(4): 680-691.
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Dong, H. #, Li, M. #, Yan, Y., Qian, T., Lin, Y., Ma, X., Vischer, H. F., Liu, C., Li, G., Wang, H., Leurs, R. and Li, Y. (2023). Genetically encoded sensors for measuring histamine release both in vitro and in vivo. Neuron. 111(10): 1564-1576.e6.
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Dong, H.#, Chen, Z.K#., Guo, H.#, Yuan, X.S.#, Liu, C.W., Qu, W.M., and Huang, Z.L. (2022). Striatal neurons expressing dopamine D1 receptor promote wakefulness in mice. Current Biology 32, 600-613 e604.
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Chen, Z.K. #, Dong, H. #, Liu, C.W. #, Liu, W.Y., Zhao, Y.N., Xu, W., Sun, X., Xiong, Y.Y., Liu, Y.Y., Yuan, X.S., Wang, B., Lazarus, M., Chérasse, Y., Li, Y.D., Han, F., Qu, W.M., Ding, F.F. and Huang, Z.L. (2022). A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy. Cell Discovery 8(1): 115.
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Yang, Y.F.#, Dong, H.#, Shen, Y., Li, L., Lazarus, M., Qu, W.M., and Huang, Z.L. (2021). Mesencephalic dopamine neurons are essential for modafinil-induced arousal. British Journal of Pharmacology 178(24): 4808-4825.
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Yuan, X.S.#, Wang, L.#, Dong, H.#, Qu, W.M., Yang, S.R., Cherasse, Y., et al. (2017). Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus. eLife 6. doi: 10.7554/eLife.29055.
Address：Room 305 on the third floor of 18# Building at Songjiang hospital,
NO. 746 Zhongshan middle Road Songjiang District, Shanghai, P.R.China 201699
Email：huidong@shsmu.edu.cn