Song Guo Zheng, M.D., Ph.D., Chair Professor of Shanghai Jiao Tong University School of Medicine
Dean, School of Cell & Gene Therapy
Principal Investigator, State Key Laboratory of Immunotherapy
Email:Song.Zheng@shsmu.edu.cn
Development and function of regulatory T cells, Immunology of Mesenchymal stem cells, Immunology of Autoimmune Diseases and tumor
Education
PhD of Immunology and Molecular Biology, French CNRS and University of Orleans
Master of Pathology and Immunology, Fudan University
B.S.Med, Anhui Medical University
Working experience
2023-Present, Chair Professor of Shanghai Jiao Tong University School of Medicine; Dean, School of Cell & Gene Therapy
2022-2023, Professor of Sun Yat-sen University
2018-2022, Ronald L. Whisler Chair in Rheumatology and Immunology, Professor of
Internal Medicine (tenure) and Director of Rheumatology and Immunology Research,
Division of Rheumatology and Immunology, Department of Internal Medicine
Ohio State University College of Medicine and Wexner Medical Center
2013-2018, Full Professor of Medicine (tenure) and Director, Rheumatology Research,
Division of Rheumatology, Department of Medicine, Penn State University Hershey College of Medicine
2009-2013, Associate Professor, Division of Rheumatology and Immunology,
Keck School of Medicine, University of Southern California, Los Angeles, CA
2004-2008, Assistant Professor, Division of Rheumatology and Immunology,
Keck School of Medicine, University of Southern California, Los Angeles, CA
2003-2004, Visiting Assistant Professor, Division of Rheumatology and Immunology,
Keck School of Medicine, University of Southern California, Los Angeles, CA
2000-2002, Postdoctoral Fellow, Division of Rheumatology and Immunology,
Keck School of Medicine, University of Southern California, Los Angeles, CA
1999-2000, Visiting Scientist, Pathology and Laboratory Medicine Department, School of Medicine, University of California, Los Angeles, CA,
1998-1999, Associate Professor, Director of Laboratory of Molecular Biology, Cancer Hospital,Shanghai Medical University
Achievements and Awards
Prof Zheng was the recipient of James Klinenberg Award, National Foundation Committee Overseas Cooperation Youth Fund Award, Freda Newton Memorial Award, Dona Foundation Immunologist Award, ACR Investigator Award, NIH STARA ward, Edmund Dubois Award and Distinguished Clinical Immunologist Award. Prof. Zheng was appointed as Editor-in-Chief of Am J Clin Exp Immunol, Associate Editor of J of Mol Cell Bio and Medcomm, Editorial Board Member of Cytokine & Growth Factor Reviews, Mol Cell Immunol, Frontiers Immunol, Theranostics, Molecular Therapy.
As a senior investigator, Prof. Zheng participated in the discipline evaluation of nine national foundations, including China, the United States, the United Kingdom, France, Canada, Australia, Poland, the Czech Republic, and South Africa, and led the project evaluation as the leader of the Rheumatoid, Skin and Oral diseases expert evaluation group of NIH in the United States. Prof. Zheng has been committed as the chairman and vice chairman of several international scientific societies and organizations. At present, more than 210 high-level papers have been published, and the papers have been widely cited at about 18,000 times. In addition, Prof. Zheng edited four English medical monographs.
Prof. Zheng is the expert the "Thousand Talents Program" of the Organization Department of the CPC Central Committee, and the Principal Investigator of National Key Research and Development Program of China. Prof. Zheng has been engaged in the pathogenesis and immunotherapy research of autoimmune and inflammatory diseases for decades, and has made series of international original achievements. Internationally, Prof. Zheng was the pioneer to discover TGF-β-induced regulatory T cells and one of the international pioneers in the field of dental mesenchymal stem cells. Up to now, several distinguished young scientists have been grown up under the assistance and guidance of Prof. Zheng. In the future, Prof. Zheng and his team will devote to the biological and clinical translational applications of immunomodulatory T cells and gingival mesenchymal stem cells, as well as the investigation of immuno-negative regulation intervention strategies in inflammatory diseases.
- Yaqian Sun Email:yaqiansun1994@163.com Research Direction:NK cell and tumor immunology
- Rongzhen Liang Email:rongzhenliang2023@163.com Research Direction:Stability and function of Treg
- Yiding Xiong Email:784394110@qq.com Research Direction:Macrophage and Rheumatoid Arthritis
- Qi Long Email:longq13@163.com Research Direction:Treg and skin immune system
- Jun Zhao Email:zhaoj278@mail2.sysu.edu.cn Research Direction:Immunology of stem cells
- Chuanxin Su Email:pd365429@shsmu.edu.cn Research Direction:Rheumatology and Neroimmunity
- Wang Wang Email:echowangwang0901@126.com Research Direction:Treg and tumor immunology
- Julie Wang Email:juliewang0906@gmail.com Research Direction:T cell differentition
- Ye Chen Email:laughye@live.cn Research Direction:Stability and regulation of Treg
- Jingrong Chen Email:jingrong.chen@shsmu.edu.cn Research Direction:Pathogenic mechanism of Rheumatoid Arthritis and Treg therapy
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Zhao J, Liu Y, Shi X, Dang J, Liu Y, Li S, Cai W, Hou Y, Zeng D, Chen Y, Yuan J, Xiong Y, Wu W, Cai P, Chen J, Sun J, Shao Y, Brand DD, Zheng SG* Infusion of GMSCs relieves autoimmune arthritis by suppressing the externalization of neutrophil extracellular traps via PGE2-PKA-ERK axis. J Adv Res,. 2023 May 9;S2090-1232(23)00127-3
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Chen J, Huang F, Hou Y, Lin X, Liang R, Hu X, Zhao J, Wang J, Olsen N, Zheng SG*. TGF-β-induced CD4+ FoxP3+ regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model. Cell Mol Immunol. 2021 Nov;18(11):2516-2529. Doi: 10.1038/s41423-021-00764-y. Epub 2021 Sep 23. PMID: 34556822
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Wu W, Xiao ZX, Zeng D, Huang F, Wang J, Liu Y, Bellanti JA, Olsen N, Zheng SG*. B7-H1 Promotes the Functional Effect of Human Gingiva-Derived Mesenchymal Stem Cells on Collagen-Induced Arthritis Murine Model. Molecular Therapy. 2020 Nov 4;28(11):2417-2429.
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Yang S, Zhang X, Chen J, Dang J, Liang R, Zeng D, Zhang H, Xue Y, Liu Y, Wu W, Zhao J, Wang J, Pan Y, Xu H, Sun B, Huang F, Lu Y, Hsueh W, Olsen N, Zheng SG*. Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts. Science Advances. 2020 Oct 28;6(44):eabb0606.
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Xiao ZX, Hu X, Zhang X, Chen Z, Wang J, Jin K, Cao FL, Sun B, Bellanti JA, Olsen N, Zheng SG*. High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways. Signal Transduct Target Ther. 2020 Apr 10; 5(1):34. Doi: 10.1038/s41392-020-0139-5. PubMed PMID: 32296043
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Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, Wu Q, Chen Z, Gao Z, Fan H, Tsun A, Shen J, Chen G, Liu Z, Lou Z, Olsen NJ, Zheng SG*, Li B. Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1. Proc Natl Acad Sci U S A. 2015;112:E3246-54.
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Lu L, Lan Q, Li Z, Zhou X, Gu J, Li Q, Wang J, Chen M, Liu Y, Shen Y, Brand DD, Ryffel B, Horwitz DA, Quismorio FP, Liu Z, Li B, Olsen NJ, Zheng SG*. Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions. Proc Natl Acad Sci U S A. 2014; 111(33):E3432-40.
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Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA. IL-2 is essential for TGF-beta to convert CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol 2007, 178:2018-2027
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Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol. 2004 May 1;172(9):5213-21
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Zheng SG, Dray JD, Ohtsuka K, Yamagiwa S, Horwitz DA: Generation ex–vivo of TGF-beta producing regulatory T cells from CD4+CD25- precursors. J Immunol 169:4183– 4189, 2002.