Location:
Xin Chen, Ph.D., Investigator
E-mail:xinchen@shsmu.edu.cn
Work Phone:021-67722498
Brain tumor mechanics and function of mechanosensitive ion channels
Educational Experience
2011-2015 University of Chinese Academy of Sciences (Ph.D. in Neurobiology)
2009-2011 University of Chinese Academy of Sciences (M.Sc. in Neurobiology)
2005-2009 Wuhan University (B.S. in Biology)
Professional Experience
2023- Investigator, Shanghai Jiao Tong University, School of Medicine
2015-2022 Postdoctoral research fellow, The Hospital for Sick Children, University of Toronto
Xin Chen
One important physical hallmark of brain tumors is the alteration of tissue mechanical properties, but little is known about the way by which tumor cells sense and respond to their mechanical microenvironment. Based on our previous discoveries, we seek to further investigate how mechanosensitive ion channels confer mechanosensitivity to the tumor and tumor-associated cells to regulate cancer progression. Investigating mechanosensitive ion channels in brain tumors represents a new frontier to discover therapeutic opportunities by revealing novel mechano-electrical-chemical signaling mechanism in cancer biology and providing effective treatment targets for precision medicine in brain tumors. We will investigate:
1. How mechanosensitive ion channels link physical traits to biochemical features in brain tumor stem cells to regulate their transit from quiescent state to activated state?
2. Whether the biomechanical properties of neuronal and glial cells are coupled with their electrical and biochemical features to regulate brain tumor initiation, progression, metastasis, and drug resistance? How mechanosensitive ion channels are involved in these processes?
3. How mechanosensitive ion channels perceive biophysical cues to control the mechanics of neuroimmune system, and regulate the development of cancer within nervous system?
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Lu Junmei,associate researcher
Email:junmeilu5@sina.com
Research Direction:Mechanical properties and neuroregulation of glioma
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Nan Shi,Research Assistant
Email:
Research Direction:Mechanical properties and neuroregulation of peripheral tumors
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Jun Wu,Research Assistant
Email:
Research Direction:Mechanical properties and metabolic regulation of tumor
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Yangyang Chen,Research Assistant
Email:
Research Direction:Mechanical properties and neuroregulation of medulloblastoma
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Alexander T Bahcheli, Hyun-Kee Min, Masroor Bayati, Hongyu Zhao, Alexander Fortuna, Weifan Dong, Irakli Dzneladze, Jade Chan, Xin Chen, Kissy Guevara-Hoyer, Peter B Dirks, Xi Huang, Jüri Reimand. Pan-cancer ion transport signature reveals functional regulators of glioblastoma aggression. The EMBO Journal, 2024, 43(2):196-224.
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Xin Chen#, Ali Momin#, Siyi Wanggou#, Xian Wang, Hyun-Kee Min, Wenkun Dou, Jade Chan, Weifan Dong, Jerry J. Fan, Yi Xiong, Kamilia Talipova, Hongyu Zhao, Yuki X. Chen, Kelly Veerasammy, Adam Fekete, Sachin A. Kumar, Hongwei Liu, Qi Yang,Joe Eun Son, Zhengchao Dou, Malini Hu, Parnian Pardis, Kyle Juraschka, Laura Donovan, Jiao Zhang, Vijay Ramaswamy, Hayden Selvadurai, Peter B. Dirks, Michael D. Taylor, Lu-Yang Wang, Chi-chung Hui, Rinat Abzalimov, Ye He, Yu Sun, Xuejun Li*, and Xi Huang*. Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity. Neuron, 2023, 111: 1-19. (Cover Article)
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Xin Chen, Siyi Wanggou, Ankur Bodalia, Min Zhu, Weifan Dong, Jerry J. Fan, Wen Chi Yin, Hyun-Kee Min, Malini Hu, Diana Draghici, Wenkun Dou, Feng Li, Fiona J. Coutinho, Heather Whetstone, Michelle M. Kushida, Peter B. Dirks, Yuanquan Song, Chi-chung Hui, Yu Sun, Lu-Yang Wang, Xuejun Li, and Xi Huang. A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression. Neuron, 2018, 100(4):799-815 (Best of Neuron 2018 and 2019)
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Xin Chen, Mei-Yu Ruan, and Shi-Qing Cai. KChIP-like Auxiliary Subunits of Kv4 Channels Regulate Excitability of Muscle Cells and Control Male Turning Behavior during Mating in Caenorhabditis elegans. Journal of Neuroscience, 2015, 35:1880 –1891.
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Ali Momin#*, Shahrzad Bahrampour#, Hyun-Kee Min#, Xin Chen#, Xian Wang, Yu Sun, and Xi Huang*. Channeling force in the brain: mechanosensitive ion channels choreograph mechanics and malignancies. Trends in Pharmacological Sciences, 2021, 42(5):367-384 (Invited Review, Cover Article)
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Yi Xiong#, Yihao Zhang#, Na Liu, Yueshuo Li, Hongwei Liu, Qi Yang, Yu Chen, Zhizhi Xia, Xin Chen*, Siyi Wanggou* and Xuejun Li*. Integration of single-cell regulon atlas and multi-omics data for prognostic stratification and personalized treatment prediction in human lung adenocarcinoma. Journal of Translational Medicine, 2023, 25;21(1):499.
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Biren M Dave, Xin Chen, Fraser McCready, Connor S Charton, Rachel M Morley, Jignesh K Tailor, James Ellis, Xi Huang, and Peter B Dirks. Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis. Development, 2023, 150(13): dev201534.
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Wentian Tang, Xin Chen, Xian Wang, Min Zhu, Guanqiao Shan, Tiancong Wang, Wenkun Dou, Jintian Wang, Juhui Law, Zheyuan Gong, Sevan Hopyan*, Xi Huang*, and Yu Sun*. Indentation Induces Instantaneous Nuclear Stiffening and Unfolding of Nuclear Envelop Wrinkles. Proceedings of the National Academy of Sciences, 2023，120(36):e2307356120.
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Xian Wang#, Tiancong Wang#, Xin Chen, Junhui Law, Guanqiao Shan, Wentian Tang, Zheyuan Gong, Peng Pan, Xinyu Liu, Jiangfan Yu, Changhai Ru*, Xi Huang*, and Yu Sun*. Microrobotic Swarms for Intracellular Measurement with Enhanced Signal-to-Noise Ratio. ACS nano, 2022, 16(7): 10824-10839.
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Wenkun Dou, Abdelkader Daoud, Xin Chen, Tiancong Wang, Manpreet Malhi, Zheyuan Gong, Fatemeh Mirshafiei, Min Zhu, Guanqiao Shan, Xi Huang, Jason T. Maynes*, and Yu Sun*. Ultrathin and flexible bioelectronic arrays for functional measurement of iPSC-cardiomyocytes under cardiotropic drug administration and controlled microenvironments. Nano Letters, 2023, 23(6): 2321-2331.
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Michael Pryszlak#, Mallory Wiggans#, Xin Chen, Shyam Patel, Julia Jaramillo, Sarah Burns, Laura Richards, Trevor Pugh, David Kaplan, Xi Huang, Peter Dirks, and Bret J. Pearson. The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. Cell Reports, 2021, 34(13):1-16
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Zhuoran Zhang, Changsheng Dai, Guanqiao Shan, Xin Chen, Hang Liu, Khaled Abdalla, Iryna Kuznyetsova, Sergey Moskovstev, Xi Huang, Clifford Librach, Keith Jarvi and Yu Sun. Quantitative selection of single human sperm with high DNA integrity for intracytoplasmic sperm injection.. Fertility and Sterility, 2021, 116(5):1308-1318
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Xian Wang, Zheyuan Gong, Tiancong Wang, Junhui Law, Xin Chen, Siyi Wanggou, Jintian Wang, Binbin Ying, Michelle Francisco, Weifan Dong, Yi Xiong, Jerry J. Fan, Graham MacLeod, Stephane Angers, Xuejun Li, Peter B. Dirks, Xinyu Liu, Xi Huang*, Yu Sun*. Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes. Science Advances, 2023, 9(13): eade5321
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Michelle A. Francisco, Siyi Wanggou, Jerry J. Fan, Weifan Dong, Xin Chen, Ali Momin, Namal Abeysundara, Hyun-Kee Min, Jade Chan, Rochelle McAdam, Marian Sia, Ronwell J. Pusong, Shixuan Liu, Nish Patel, Vijay Ramaswamy, Xiaochong Wu, Noriyuki Kijima, Lu-Yang Wang, Yuanquan Song, Ran Kafri, Michael D. Taylor, Xuejun Li*, and Xi Huang*. Chloride intracellular channel 1 cooperates with potassium channel to promote medulloblastoma growth. Journal of Experimental Medicine, 2020, 217(5):1-19
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Qiang Jiang#, Kai Li#, Wen-Jing Lu, Shuang Li, Xin Chen, Xi-Juan Liu, Jie Yuan, Qiurong Ding, Feng Lan*, and Shi-Qing Cai*. Identification of small-molecule ion channel modulators in C.elegans channelopathy models. Nature Communications, 2018, 9(1):1-12
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Weifan Dong, Adam Fekete, Xiaodi Chen, Hongwei Liu, Greg Beilhartz, Xin Chen, ShahrzadBahrampour, Yi Xiong, Qi Yang, Hongyu Zhao, Tian Kong, Malia Morioka, Geena Jung, Ji-EunKim, Daniel Schramek, Peter B. Dirks, Yuanquan Song, Tae-Hee Kim, Ye He, Siyi WanggouXuejun Li, Roman Melnyk, Lu-Yang Wang, Xi Huang. A designer peptide to treat glioblastomaby targeting EAG2-Kvβ2 potassium channel complex-mediated cancer-neuron interaction. NatureCancer, 2023,4(10):1418-1436.
