Email: hanwenjian@picb.ac.cn

Research direction: Design of RNA binding proteins and base editing proteins

2018.9-2021.6 University of Chinese Academy of Sciences, Ph.D. in Computational Biology

2013.9-2016.6 Master of Biochemistry and Molecular Biology, Shanghai Normal University

2009.9-2013.6 Linyi University, Bachelor of Biological Sciences

2023.6-present Young Associate Researcher, Songjiang Research Institute, School of Medicine, Shanghai Jiao Tong University

2021.7-2023.6 Center of Excellence in Brain Science and Intelligent Technology, Chinese Academy of Sciences, Postdoctoral Fellow

2016.7-2018.8 Research Intern at Max Planck Institute of Computational Biology, Chinese Academy of Sciences

(1)Wenjian Han*;Wendi Huang*; Tong Wei; Yanwen Ye; Miaowei Mao; Zefeng Wang; Programmable RNA base editing with a single gRNA-free enzyme,Nucleic Acids Research, 2022

(2) Cheng Zhang*; Mengyi Ren*;Wenjian Han*; Yafei Zhang; Minjia Huang; Siyuan Wu; Jie Huang; Yun Wang; Zheng Zhang; Zhongnan Yang; Slow development allows redundant genes to restore the fertility of rpg1, a TGMS line in Arabidopsis,The Plant journal, 2022

(3) Yue Sun; Yufang Bao;Wenjian Han; Fan Song; Xianfeng Shen; Jiawei Zhao; Ji Zuo; David Saffen; Wei Chen; Zefeng Wang; Xintian You; Yongbo Wang; Autoregulation of RBM10 and cross-regulati on of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay,Nucleic Acids Research, 2017

(1) National Natural Science Foundation of China, Youth Science Foundation Project,82201632, Artificially Designed programmable RNA base Editing Enzyme to Repair pathogenic Point mutations in the nervous System, 2023-01 to 2025-12,300 yuan, Research in progress, Host.

(2) The second-class project funded by the 72nd batch of China Postdoctoral Science Foundation (2022M723244), developing a novel C-to-U RNA base editor to repair pathogenic mutations of ASD-related gene Mef2c, 2022 to 20238,000 yuan, in research, host.

(3) Shanghai Municipal Bureau of Human Resources and Social Security, Shanghai "Super Postdoctoral" funding project (2022777), Construction of a new generation of programmable RNA base editing platform and its application in the treatment of nervous system related diseases, 2022 to 2023,300,000 yuan, in research, presided over.

(4) National Natural Science Foundation of China, Joint Fund Project,U22A20294, Study on the effect of APOE4 in Alzheimer's Disease on the immune function of bone marroe-derived monocyte and Gene editing intervention Strategy,2023-01-01 to 2026-12-31, 2.55 million yuan, in research, head of Party B.

(5) National Natural Science Foundation of China, Key Project,32030064, Artificial Construction of modular RNA binding factors to Accurately Modify RNA bases,2021-01-01 to 2025-12-31, 2.93 million yuan, ongoing research, participate.

(6) National Natural Science Foundation of China, Surface Project,31971367, Construction and application of a high-precision artificial endonuclide system targeting mitochondrial RNA, 2020-01-01 to 2023-12-31, 590,000 yuan, ongoing research, participation.

(7) Shanghai Science and Technology Commission, Basic Research Project,17JC1404900, Artificial Construction of modular RNA binding factors as a new tool for gene Therapy to manipulate RNA metabolism, 2017-09-- 2020-88 million yuan, Concluded, Participated.