E-mail address：yegentang2022@163.com

Research Direction：The function and mechanisms of cell death and inflammation in human diseases

Education：

2007.9-2011.6  School of life sciences, Huzhou University, Bachelor of Bioengineering

2011.9-2014.6  College of forestry and biotechnology, Zhejiang agriculture and Forestry University, Master

2018.9-2023.6  Biomedical Research Institute of Fudan University,Doctoral candidate in Chemical Biology

Work Experience：

2015.6-2018.8  Biomedical Research Institute of Fudan University, Research assistant

Publications:

1. Maohua Yang 1 , Yegen Tang 1 , Jingwei Weng*, Zhijun Liu*, Wenning Wang*. The Role of

Calcium in Regulating the Conformational Dynamics of D-Galactose/D-Glu cose-Binding

Protein Revealed by Markov State Model Analysis. Journal of Chemical Information and

Modeling. 2021, 61, 891-900. ( 1First two authors contributed equally)

2. Chenxiao Jiang 1 ,Yegen Tang 1 ,Lulu Ding 1 ,Renke Tan,Yu Ding*,Jianwei Liu*,Yongjun

Dang*.Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling.Cell

Chemical Biology.2019,26,1417-1426.

3. Lei JT, Qi RX, Yegen Tang, Wang WN, Wei GH, Nussinov R, et al. Conformational

stability and dynamics of the cancer-associated isoform 133p53 are modulated by p53

peptides and p53-specific DNA. Faseb J. 2019;33(3):4225-35.

4. Yegen Tang, Maohua Yang，Jingwei Weng*, Zhijun Liu*, Wenning Wang*.Conformational

Dynamics of Holo-GGBP Revealed by Experimental and Computational Analysis. (in

preparation)

5. Yegen Tang, Maohua Yang，Zhijun Liu*, Wenning Wang*.Multiple conformational states and

Conformational Dynamics regulate the GlucoseGalactose binding protein.(under review)

Participated projects:

1. National Basic Research Program of China(973 Program)，Construction of SOC1

regulatory network of flower forming key gene of Phyllostachys pubescens

2. National Natural Science Foundation of China，Usp9x regulates protein translation

initiation through deubiquitination eIF4B and its application in tumor targeted therapy

3. National Natural Science Foundation of China，Development of a new AFM optical

composite imaging system and its role in cardiomyocyte mechanical properties and

drug screening National Natural Science Foundation of China，Study on conformational

changes and transport mechanism of vitamin B12 input protein BtuCD