Ruilong Xia, Postdoc.

E-mail address：xiaruilong@hotmail.com

Research Direction：The function and mechanisms of cell death and inflammation in human diseases

Education：

2019.9-2023.7   Tongji University Clinical Medicine(neurobiology), Doctor

2011.9-2014.3   Zhejiang Sci-Tech University Biochemistry and molecular biology, Master

2007.9-2011.6   Zhejiang Sci-Tech University Biotechnology, Bachelor

Work Experience    

2017.10-2019.8  Tongji University Research assistant

2014.05-2017.8  Zhejiang Wolwo Bio-Pharmaceutical Co., Ltd Academic Specialist

Publications:

(1)Ruilong Xia et al. MiR-96 promotes maintenance of hearing and protects hearing against noise. (the article is currently being prepared for submission);

(2)Li Ting Sun#, Rui Long Xia #, Jin Wen Jiang, Ting Wen, Zhuo Ya Huang, Ran Qian, Ming-Dong Zhang, Ming Cheng Zhou, Chang Geng Peng. MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord. Progress in Neurobiology, 2021,202:102024 (co-first author, Q1);

(3)Li ting Sun#, Hang Xian#, Yun xin Shi#, Tao tan Yang#, Hongyan Shuai#, Ruilong Xia, Ting Wen, Wei Xia, Ran Qian, Feng ting Zhu, Yuan ying Liu, Zhi cheng Tian, Lamei Li, Rui Cong, Ceng Luo, Shengxi Wu, Xia feng Shen, Xin Yu, Rou-Gang Xie, Chang geng Peng. Nav1.7 and Nav1.8 form supramolecular active clusters with TRKB in mouse and human DRG neurons during development of neuropathic pain. (https://www.medrxiv.org/content/10.1101/2022.11.05.22281929v1);

(4)Rui Long Xia, Cai-Yun Fu, Shi-Fu Zhang, Yuan-Ting Jin, Fu-Kun Zhao. Study on the distribution sites and the molecular mechanism of analgesia after intracerebroventricular injection of rat/mouse hemokinin-1 in mice. Peptides, 2013, 43:113-120. (Q2);

(5)Rui Long Xia #, Yan Lu #, Li Na Zhu, Shi Fu Zhang, Fu Kun Zhao, Cai Yun Fu. Different regulatory pathways are involved in the proliferative inhibition of two types of leukemia cell lines induced by paclitaxel. Oncology Reports, 2013, 30:1853-1859. (Q3);

(6)Cai Yun Fu, Rui Long Xia, Teng Fei Zhang, Yan Lu, Shi Fu Zhang, Zhi Qiang Yu, Tao Jin, Xiao Zhou Mou. Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice. PLOS ONE, 2014, 9(2): e90446.doi:10.1371/journal.pone.0090446. (Q2);

(7)Yan Fu, Li ting Sun, Feng ting Zhu, Wei Xia, Ting Wen, Ruilong Xia, Xin Yu, Dan Xu, Chang geng Peng. Nav1.7 in spinal dorsal horn neurons induced by NGF contributes to neuropathic pain in a mouse spinal cord injury model. Front Mol Neurosci. 2023;16:1091096.(Q1);

(8)Rong chuan Zhao, Jiao Yang, Yun jiao Zhai, Hong Zhang, Yuan shuai Zhou, Lei Hong, De tian Yuan, Ruilong Xia, Yan xiang Liu, Guohua Shi, Ruo bing Zhang, Ding san Luo, Jin yun Yuan, Chang geng Peng, Shi yang Li, Min xuan Sun. Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activity. (under review);

(9)Zhi bin Yan, Xiang yu Hong, Qi hao Lin, Lei jie Wang, Gang Shao, Chen tao Ge, Ruilong Xia, Cai yun Fu. Neurokinin-2 receptor antagonist SR48968 induced necroptosis of myeloid leukemia cells by calcium overload-driven reactive oxygen species accumulation. Genes & Diseases (acception).

Patents

(1) One analgesic and itching relieving drug composition and its use method, 2021-01-15, WIPO, application number: WOCN21072071 (invention patent, transferred).

(2) One pain and itching relieving drug composition and its application method, 2020-08-20, China, patent number ZL202010845095.2 (invention patent, transferred).

(3) One method for preparing TrkB tomato mice and its application, 2022-01-08, China, application number 202210052495.7 (invention patent, transferred).

(4) Analgesic and antipruritic pharmaceutical composition and application method therefor, 2023-8-3, Australia, patent number: 2021329457.

Participated projects:

2018.2-2022.12 One analgesic and itching relieving drug composition and its use method

Awards

(1) Young Pioneer Award in Brain Science at the Yangtze River Delta Neuroscience Youth Forum, 2021.

(2) Outstanding Graduate of Zhejiang Province, 2014.

(3) Outstanding Graduate of Zhejiang Sci-Tech University, 2014.

(4) Outstanding Master Degree Thesis of Zhejiang Sci-Tech University, 2014.

(5) Second Prize for Zhejiang Province "Challenge Cup" Undergraduate Student Curricular Academic Science and Technology Works Competition, 2013.

(6) National Fellowship for Graduate Students, 2013.

(7) Progressive innovation gold award for "Challenge Cup" National College Student Curricular Academic Science and Technology Works Competition, 2013.

(8) Young Investigator Award of Chinese Society for Cell Biology, Medical Cell Biology (Zhejiang Society for Cell Biology), 2013.