E-Mail：wm19921276529@163.com
Research interests: 1. Central regulatory mechanisms of anorexia nervosa; 2. Molecular mechanisms of central inflammation and metabolic disorders induced by the obesity gene MC4R
Educational Experience：
2016.09-2021.06 College of Life Science and Technology, Tongji University, Biology, Ph.D.
2012.09-2016.06 College of Life Science and Technology, Guangxi University, Biological Engineering, Bachelor
Work Experience:
2023.10 to Present Associate Researcher, Songjiang Research Institute, School of Medicine, Shanghai Jiaotong University, China
2021.09-2023.10 Postdoctoral Fellow, Basic Medicine, School of Medicine, Shanghai Jiaotong University, China
Representative papers：
1. Meng Wang*; Jianjun Lyu; Chao Zhang. Single transmembrane GPCR modulating proteins: neither single nor simple, Protein & Cell, 2023; pwad035. doi:10.1093/procel/pwad035.
2. Meng Wang*; Xiaozhu Wang*; Bopei Jiang; Yue Zhai; Jihong Zheng; Liu Yang; Xiaolu Tai; Yunpeng Li; Shaliu Fu; Jing Xu; Xiaowei Lei; Zhe Kuang; Cong Zhang; Xuanxuan Bai; Mingyu Li; Tao Zan; Shen Qu; Qingfeng Li; Chao Zhang. Identification of MRAP protein family as broad‐spectrum GPCR Modulators,
Clinical and Translational Medicine, 2022.
3. Meng Wang*; Jing Xu*; Xiaowei Lei*; Cong Zhang; Shang-Yun Liu; Li-Na Jin; Chao Zhang. Selective Interactions of Mouse Melanocortin Receptor Accessory Proteins with Somatostatin Receptors, Cells, 2022, 11(2): 267.
4. Meng Wang*; Yue Zhai; Liumei Lu; Cong Zhang; Na Li; Song Xue; Daofu Cheng; Shaliu Fu; Qi Liu; Chao Zhang. Elucidation of the dimeric interplay of dual MRAP2 proteins in the zebrafish, Journal of Cellular Physiology, 2021, 236(9): 6472-6480.
5. Meng Wang*; Linyu Pi*; Xiaowei Lei*; Lei Li; Jing Xu; Zhe Kuang; Cong Zhang; Liang Li; Chao Zhang. Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer, Frontiers in Endocrinology, 2021, 12: 750797.
6. Meng Wang*; Yue Zhai; Xiaowei Lei; Jing Xu; Bopei Jiang; Zhe Kuang; Cong Zhang; Shangyun Liu; Shan Bian; Xiao-Mei Yang; Tao Zan; Li-Na Jin; Qingfeng Li; Chao Zhang. Determination of the interaction and pharmacological modulation of MCHR1 signaling by C terminus of MRAP2 protein, Frontiers in Endocrinology, 2022, 13: 848728.
7. Meng Wang*; Yijun Chen; Ming Zhu; Bingxin Xu; Wenxuan Guo; Yunsong Lyu; Chao Zhang. Pharmacological modulation of melanocortin-4 receptor by melanocortin receptor accessory protein 2 in Nile tilapia. General and Comparative Endocrinology, 2019 Oct 1; 282:113219.
8. Jing Xu*; Meng Wang*; Yanbin Fu; Cong Zhang; Zhe Kuang; Shan Bian; Rui Wan; Shen Qu; Chao Zhang. Reversion of MRAP2 Protein Sequence Generates a Functional Novel Pharmacological Modulator for MC4R Signaling, biology, 2022, 11(6), 874.
9. Ming Zhu*; Meng Wang*; Yijun Chen; Chao Zhang. Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish, Journal of Molecular Endocrinology, 2018, 62(1):27-36.
10. Xiaozhu Wang*; Song Xue; Xiaowei Lei; Wenqi Song; Lei Li; Xuan Li; Yanbin Fu; Cong Zhang; Hailin Zhang; Yao Luo; Meng Wang（co-corresponding author）; Gufa Lin; Chao Zhang; Jing Guo. Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling, Frontiers in
Endocrinology, 2022 Feb 17; 13: 820896.
Honors and Awards：
2022 Shanghai Super Postdoctoral Incentive Program;
2022 First Prize of Science and Technology Award of Chinese Society of Rehabilitation Medicine (Research on molecular pathways of wound healing and functional reconstruction after limb transplantation and application of related rehabilitation techniques);
2016.09-2021.06 Guanghua Scholarship, Excellent Student of Tongji University, etc.
2012.09-2016.06 National Scholarship, Presidential Scholarship, Outstanding Graduate of the Autonomous Region, Outstanding Student Leader of the Autonomous Region, etc.
NSF projects/programs chaired or participated in the last five years：
1. The 72nd batch of postdoctoral top-level project second-class funding, single-cell sequencing reveals different molecular mechanisms of obesity genes Leptin and MC4R mediating central neuroinflammation, 2022M722127, 2022.11-2023.11, 80,000 RMB concluded, host.
2. National Natural Foundation of China (NNF) Top Project, 81570760, Study on the Evolution and Regulatory Mechanism of MRAP2 as Melanocortin Fourth Receptor MC4R Auxiliary Protein, 2016.01-2019.12, 580,000 RMB, concluded, participated.
3. National Natural Foundation of China (NNF) Top Project, 31771283, Study of single-cell transcriptome and pharmacological regulatory mechanism of MC4R neurons using zebrafish model, 2018.01-2021.12, 600,000 RMB, concluded, participated.
Location:
