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王杰 研究员
邮箱：jie.wang@shsmu.edu.cn
研究方向：磁共振成像与病毒示踪技术在麻醉与睡眠领域应用
教育经历
2007-2009 耶鲁大学 生物医学工程 联合培养博士
2004-2009 兰州大学化学化工学院 博士
2000-2004 兰州大学，化学，学士
工作经历
2024-至今 欧洲杯竞猜平台松江研究院 课题组长
2017-2024 中科院精密测量院，研究员
2012-2017 中科院武汉物数所，副研究员，
2009-2012 中科院武汉物数所，助理研究员，
2010-2013 耶鲁大学 博士后
王杰 研究员
课题组围绕磁共振成像技术，系统整合光/药理遗传学、光纤钙记录、膜片钳、电生理等前沿神经科学技术解析脑疾病的发生发展机制，团队重点关注麻醉与失眠障碍等相关研究领域。具体包括以下三个研究内容：
1）系统整合前沿神经科学技术解决麻醉与失眠障碍的发生机制，并探索失眠障碍的非药物干预新疗法，为临床应用奠定基础；
2）整合病毒示踪建立基因编码磁共振成像技术，实现特异类型细胞的活体全脑检测；
3）与临床团队紧密合作，进行人脑磁共振影像的数据深度挖掘(尤其是治疗前后的对比分析)，旨在筛选失眠障碍及精神疾病的脑影像学特征及相应的干预靶点脑区，为临床推广提供理论依据。
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Jinfeng Wu#, Kangguang Lin#, Weicong Lu , Wenjin Zou , Xiaoyue Li , Yarong Tan , Jingyu Yang , Danhao Zheng , Xiaodong Liu , Bess Yin-Hung Lam , Guiyun Xu , Kun Wang , Roger S，McIntyre , Fei Wang , Kwok-Fai So , Jie Wang*;Enhancing Early Diagnosis of Bipolar Disorder in Adolescents through Multimodal Neuroimaging, Biol Psychiatry, 2024:S0006-3223(24)01485-9
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Jie Wang, Wenfeng Zhao, Huang Wang, Haixia Leng, Qing Xue, Mao Peng, Baoquan Min, Xiukun Jin, Liucen Tan, Keming Gao, Hongxing Wang*, Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder, General Psychiatry (IF:11.9), 2024;37:e101338.
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Xiaolin Liang#, Meng Gong#, Zhikai Wang#, Jie Wang#, Weiwei Guo#, Aoling Cai, Zhenye Yang, Xing Liu, Fuqiang Xu, Wei Xiong*, Chuanhai Fu*, Xiangting Wang*; LncRNA 1 TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination, Cell Discovery (IF:13.0), 2024;10(1):54.
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Weicong Lu#, Jinfeng Wu#, Robin Shao*, Wenjin Zou, Ruoxi Zhang, Xiaoyue Li, Jiehua Kong, Danhao Zheng, Xinhe Tian, Yanling Gao, Sonata Yau, Benjami Goldstein, Guiyun Xu, Kwok-Fai So, Jie Wang,* Kangguang Lin; Genetic and symptomatic risks associated with longitudinal brain morphometry in bipolar disorder, Nature Mental Health, 2024，2, 209–217.
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Jinpiao Zhu#; Chang Chen#; Xiaodong Liu; Mengying He; Yuanyuan Fang; Li Wang, Junke Jia, Juan Guo; Ziyue Zhao; Chenyi Gao; Jingang He; Fuqiang Xu; Daqing Ma*; Jie Wang*; Zongze Zhang*，Cerebellar Purkinje cell firing promotes conscious recovery from anaesthesia state through coordinating neuronal communications with motor cortex，Theranostics, 2024; 14(2):480-495
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Yuanyuan Qin#; Jinfeng Wu#; Tao Chen#; Jia Li; Guiling Zhang; Di Wu; Yiran Zhou; Ning Zheng; Aoling Cai; Qin Ning; Anne Manyande; Fuqiang Xu; Jie Wang*; Wenzhen Zhu*; Long-term micro-structure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations, Journal of Clinical Investigation, 2021, 131(8): e147329 .
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Mei Li#, Zhuang Liu#, Yang Wu, Ning Zheng, Xiaodong Liu, Aoling Cai, Danhao Zheng, Jinpiao Zhu, Jinfeng Wu, Lingling Xu, Xihai Li, Ling-Qiang Zhu, Anne Manyande, Fuqiang Xu*, Jie Wang*, In vivo Imaging of Astrocytes in the Whole Brain with Engineered AAVs and Diffusion Weighted Magnetic Resonance Imaging, Molecular Psychiatry, 2024;29(3):545-552
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Jinpiao Zhu#, Chang Chen#, Jinfeng Wu, Mengying He, Shuang Li, Yuanyuan Fang, Yan Zhou, Haibo Xu, Saeed Sadigh-Eteghad, Anne Manyande, Feng Zheng, Ting Chen, Fuqiang Xu, Daqing Ma, Jie Wang*, Zongze Zhang*, Propofol ameliorates social and anxiety-related behaviours through enhancing mPFC functional connectivity in the sleep-deprived rat: In comparison with sevoflurane, British Journal of Anaesthesia, 2023, 131(3): 531-541.
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Yaqing Shu#; Fuhua Peng#; Bingchu Zhao; Chunxin Liu; Qihui Li; Huilu Li; Yuge Wang; Yanjun Jiang; Tingting Lu; Qin Wang; Jian Sun; Huiyu Feng; Zhengqi Lu; Xiaodong Liu*; Jie Wang*; Wei Qiu*; Transfer of patient’s peripheral blood mononuclear cells (PBMCs) disrupts blood–brain barrier and induces anti-NMDAR encephalitis: a study of novel humanized PBMC mouse model, Journal of Neuroinflammation, 2023, 20: 164.
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Tian Tian#, Jinfeng Wu#, Tao Chen, Jia Li, Su Yan, Yiran Zhou, Xiaolong Peng, Yuanhao Li, Ning Zheng, Aoling Cai, Qin Ning, Hongbing Xiang, Fuqiang Xu, Yuanyuan Qin*, Wenzhen Zhu*, Jie Wang*, Long-term follow-up studies for dynamic brain changes in recovered COVID-19 patients without neurological manifestations. JCI insight, 2022, 7(4): e155827